Gordon Research Conference On Cell Contact And Adhesion

描述（由申请人提供）：申请资助将于2002年6月8日至13日在新罕布什尔州安多弗普罗科特学院举行的第十六届（30年）戈登会议“细胞接触和粘附”。这次会议的持久性证明了它作为细胞-细胞相互作用领域的关键会议的重要性。它是跨学科的，包括分子、结构、遗传和细胞的方法来解剖细胞-细胞接触的结构，确定它们的细胞、组织学和有机体的作用，以及它们在包括癌症和发育缺陷在内的人类疾病中的作用。今年会议的重点将是粘接和闭塞型细胞-细胞接触在形态发生中的作用。这次会议将引起分子、细胞、癌症和发育生物学家的兴趣。会议涵盖了令人兴奋和最新进展的领域，包括：细胞接触在细胞极性、不对称细胞分裂和平面极性中的作用。两场会议将涵盖细胞接触在干细胞存活和细胞命运决定中的作用。这个主题已经引起了很大的兴奋，并将在血管和心脏系统，表皮和乳腺中进行探索。三场会议将涵盖细胞接触蛋白及其相关接头蛋白在控制增殖控制、细胞骨架重组、癌症和转移的信号转导过程中的作用。演讲者名单包括在这一领域活跃的知名科学家，以及最近贡献了精辟数据的年轻研究人员和初级学员。选择这些主席是因为他们能够就广泛的主题引发讨论。按照本次会议的传统，在最后一届会议上保留了四个时段，以纳入最新的突破性发展，并在每届会议结束时分配了一个简短的谈话时段，以突出有前途的年轻研究人员的工作。

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Conference "Cell Contact and Adhesion" that will be held for the sixteenth time (30th year), June 8-13, 2002 at Proctor Academy, Andover, NH. The endurance of this conference testifies to its importance as a key meeting for the field of cell-cell interactions. It is interdisciplinary, encompassing molecular, structural, genetic and cellular approaches to dissecting the architecture of cell-cell contacts, determining their cellular, histological, and organismal roles and their involvement in human disease including cancer and developmental defects. The focus of this year's meeting will be the role of adhesive and occludens type cell-cell contacts in morphogenesis. The conference will interest molecular, cell, cancer and developmental biologists. The sessions cover areas of exciting and recent progress including: The role of cell contacts in: cell polarity, asymmetric cell division and planar polarity. Two sessions will cover the role of cell contacts in stem cell survival and cell fate determination. This theme has generated much excitement and will be explored in the vascular and cardiac system, epidermis and mammary gland. Three sessions will cover the role of cell contact proteins and their associated adaptor proteins in signal transduction processes governing proliferative control, cytoskeletal reorganization, cancer and metastasis. The roster of speakers includes established and renowned scientists who are active leaders in this field as well as young investigators and junior trainees who have recently contributed incisive data. The chairs have been chosen for their ability to generate discussion on a wide range of topics. As is traditional for this meeting, four slots have been reserved in the last session for the inclusion of late breaking developments and a short talk slot has been allocated at the end of each session to highlight the work of promising young investigators. This conference will bring together scientists working in vertebrate and invertebrate systems who do not meet in other forums. The components of cell-cell contacts are tumor suppressors and oncogenes and thus this conference will be highly relevant for the mission of the NCI. Cell-cell contact proteins provide the physical force that unite cells into functional tissues during embryogenesis and, as the genetic approaches highlighted in this meeting show, defects in these components lead to birth defects that are highly relevant to the mission of NICHD. This conference is also relevant to the mission of, and will report research that is also funded by NIDDK, NIAMS, NHLBI and NIGMS.