Conference--Molecular & Cellular Bioenergetics

描述(申请人提供)：最近更名为分子和细胞生物能量学的戈登会议上一次召开是在2001年6月，下一次会议将于2003年6月22-27日在密西西比州梅里登的金博尔联合学院举行。这次会议的传统焦点是氧化磷酸化和电子传递的机制，这些仍然是下一次会议的中心议题。借助F1F0 ATP合成酶复合体的高分辨率结构数据和旋转运动的新的动态测量的应用，对质子偶联ATP合成的机制有了重要的见解。同样，随着呼吸链复合体新的高分辨结构的出现，人们对电子传递、质子运动以及这两个过程之间的耦合的分子机制也有了更深入的了解。此外，本次会议已扩大为讨论利用X射线结晶学、光谱技术和分子生物学方法获得的关于膜整体运输蛋白的机制信息的主要平台。最近讨论的系统包括细菌视紫红质、卤视紫质和水通道蛋白，而ABC转运蛋白的高分辨率结构将在2003年会议上介绍。此外，这次会议还扩展到细胞生物能量学和疾病，于2003年介绍了V-ATPase的功能和调节，生物能复合体的组装和靶向机制，以及铜吸收缺陷和对细胞内寄生虫的抗性的分子基础。因此，拟议的会议应该实现介绍分子和细胞生物能量学领域的尖端研究的目标。生物能量学戈登会议的与会者包括该领域的领导者，他们来自学术界、政府和工业界，以及更初级的科学家，包括许多研究生和博士后研究员，他们代表着该领域的未来。目前申请中寻求的支持的一个主要用途是帮助这些初级人员参加这次会议。组织戈登会议是为了最大限度地提供讨论和介绍这一领域最新成果的机会，每天下午举行海报会议，每次正式会议后举行讨论时段，并专门举办一个上午的讲习班，重点是海报主持人的简短介绍。

DESCRIPTION (provided by applicant): Recently renamed Molecular and Cellular Bioenergetics, this Gordon Conference was last held in June, 2001, with the next meeting to be held June 22-27, 2003 at the Kimball Union Academy in Meriden, NH. The traditional focus of this meeting is on the mechanisms of oxidative phosphorylation and electron transport, and these continue to be central themes in the next conference. Aided by high resolution structural data on the F1F0 ATP synthase complex and by the application of novel dynamic measurements of rotary motion, important insights are emerging into the mechanism of proton-coupled ATP synthesis. Similarly, with the appearance of new high resolution structures of respiratory chain complexes, insights into the molecular mechanisms involved in electron transport, proton movement and the coupling between these two processes are also emerging. Moreover, this Conference has expanded to become a major platform for the discussion of mechanistic information obtained on integral membrane transport proteins using X-ray crystallography, spectroscopic techniques and molecular biological approaches. Recently discussed systems include bacteriorhodopsin, halorhodopsin and aquaporin, while the high resolution structure of the ABC transporters will be featured at the 2003 Conference. In addition, this meeting has also expanded into cellular bioenergetics and disease, with presentations in 2003 on the function and regulation of V-ATPases, the mechanism of assembly and targeting of bioenergetic complexes and the molecular basis of defects in copper absorption and resistance to intracellular parasites. The proposed meeting should thus accomplish the goal of presenting the cutting-edge research in the area of molecular and cellular bioenergetics. The participants at the Bioenergetics Gordon Conference include the leaders in this field, drawn from academics, government and industry, as well as more junior scientists, including many graduate students and Postdoctoral fellows, who represent the future of this area. A major use of the support sought in the current application is to assist such junior people in participating in this meeting. The Gordon Conference is organized to maximize the opportunity for discussion and for the presentation of the latest findings in this area, with poster sessions occurring every afternoon, discussion periods after each formal session and one entire morning devoted to workshops focused on short presentations by poster presenters.