Synthetic Extremophiles: Cellular bionics for extreme conditions

帮助有机体在它们的生态位中生存。这种适应可以是结构性的、行为性的或生理性的。在极端微生物的情况下，这种特性延伸到使生命能够在曾经被认为无法维持生命的恶劣环境中茁壮成长：从极端压力一直到极端温度。该奖学金旨在首次产生能够在极端压力下生存的生物合成混合系统（相当于世界上最深的海洋点马里亚纳海沟底部; > 1000 atm）-合成极端微生物。通过融合生命和非生命系统，我们将产生能够根据流体静压力的外部变化修改其组成和构成的合奏。这有可能改变我们对分子成分如何聚集在一起引入紧急行为的理解。此外，它将导致生物组件的制造，非常适合于广泛的工业，生物技术和消费应用，其中极端条件下的性能和响应极端操作条件的能力是基本的先决条件。

helping organisms to survive in their ecological niches. Such adaptations can be structural, behavioural or physiological. In the case of extremophiles this trait extends to enabling life to thrive in forbidding environments that were once not thought to be able to sustain life: from extremes of pressure all the way through to extremes of temperature. This studentship aims for the first time to generate biological-synthetic hybrid systems that are capable of surviving extremes of pressure (equivalent to being at the bottom of the Mariana Trench, the deepest ocean point in the world; >1000atm)-synthetic extremophiles. By fusing living and non-living systems we will generate ensembles that are able to modify their composition and make-up in response to external changes in hydrostatic pressure. This has the potential to transform our understanding of how molecular components come together to introduce emergent behaviour. In addition, it will lead to the manufacture of biological components that are ideally suited to a wide range of industrial, bio technical and consumer applications where performance under extreme conditions and the capability to respond to extreme operating conditions are fundamental prerequisites.