Gordon Conferecnce on Oxidative Stress and Disease

描述（由申请人提供） 资金要求支持戈登研究会议氧化应激和疾病将在文图拉，加利福尼亚州举行。在2003年3月。 这将是戈登会议的第二次会议。 首届会议于2001年3月举行，取得了巨大的成功，与会者给予了出色的评价。 会议的成功很大程度上源于有效整合各种主题和疾病状态的能力，所有这些主题和疾病状态都具有氧化应激的共同主题。 在即将举行的会议上，将继续这一融合科学多样性的传统。 本报告建议召开九次科学会议。 两个处理活性氧对衰老过程的影响，然后是一个专门讨论线粒体在氧自由基应激中的作用的会议。 还包括一个关于抗氧化剂治疗的会议。 其他会议致力于以一种或另一种形式与氧化损伤相关的特定疾病状态。 这些包括神经变性、金属过载疾病、微生物病原体和癌症。 最后，会议将以关于预防氧化应激相关疾病的信号通路的会议结束。 会议的总主题是“从化学到临床”，将介绍氧化损伤的多个方面，从基本的活性氧化学到模式生物研究到人类疾病病理学。 会议将吸引化学家，生物学家和临床医生，所有人的共同目标是了解氧化损伤对健康的影响。 演讲者是根据他们的科学成就和对该领域的贡献而选出的。 对年轻调查员和妇女给予了特别考虑。 请求提供资金，以支付应邀发言者和讨论牵头人以及申请参加会议的10名初级调查员的差旅费和会议费用。

DESCRIPTION (provided by applicant) Funds are requested to support the Gordon Research Conference on Oxidative Stress and Disease to be held in Ventura, Ca. in March of 2003. This will represent the second meeting of this particular Gordon Conference. The inaugural conference was held in March of 2001 and was a big success, with outstanding reviews from the attendees. The success of the meeting largely stemmed from the ability to effectively integrate a diversity of topics and disease states, all with the common underlying theme of oxidative stress. In the upcoming meeting, this tradition of integrating scientific diversity will be continued. Nine scientific sessions are proposed herein. Two deal with the impact of reactive oxygen on the aging process, followed by a session devoted to the role of mitochondria in oxygen radical stress. A session on anti-oxidant therapeutics is also included. Other sessions are dedicated to specific disease states that have in one form or another, been associated with oxidative damage. These include neurodegeneration, diseases of metal overload, microbial pathogenic and cancer. Finally, the meeting will conclude with a session on signaling pathways for guarding against oxidative stress related disorders. The overall theme of the meeting is "from chemistry to the clinics" and multiple aspects of oxidative damage will be presented, from basic reactive oxygen chemistry to model organism studies to human disease pathology. The meeting will attract chemists, biologists and clinicians alike, all with the common goal of understanding the impact of oxidative damage on health. The speakers were selected on the basis of their scientific excellence and contributions to the field. Special consideration was given to young investigators and women. Funds are requested to support the travel and meeting expenses of the invited speakers and discussion leaders as well as 10 junior investigators that apply to the meeting.