Axonal Connections: Cues for Development & Regeneration

描述（由申请人提供）：神经系统的功能依赖于其复杂的连接模式。轴突连接最初是在发育过程中通过线索建立的，这些线索引导轴突沿着特定的途径，然后指定目标区域内的连接位点。近年来，在分子识别这些线索方面取得了巨大进展。基于这一进展，目前的研究正在阐明建立连接的细胞外信号的分子逻辑，以及解释这些信号的细胞内通路。在成人中枢神经系统中，受损的轴突连接不能再生，尽管周围神经可以有效地再生。这至少部分是由于中枢神经系统抑制剂，其中一些现已被克隆。这次会议将汇集发展和再生领域，目的是促进技术、分子和生物学方面的协同重叠。主题将包括分子线索的基础研究，以及由此产生的治疗性轴突修复的新方法。

DESCRIPTION (provided by applicant): The functioning of the nervous system depends on its complex pattern of connections. Axonal connections are initially set up during development by cues, which guide axons along specific pathways and then specify connection sites within the target region. In recent years, dramatic progress has been made in identifying such cues molecularly. Based on this progress, current studies are elucidating the molecular logic of extracellular signals that set up connectivity, as well as intracellular pathways that interpret these signals. In the adult central nervous system, damaged axonal connections do not regenerate, even though peripheral nerves can regenerate efficiently. This is due at least in part to CNS inhibitors, some of which have now been cloned. This meeting will bring together the fields of development and regeneration, with the goal of facilitating synergistic overlaps in techniques, molecules and biology. Topics will include basic research on molecular cues, and resulting new approaches toward therapeutic axon repair.