MEETINGS ON MODELING HUMAN CANCER IN MICE

结直肠癌是美国癌症死亡的第二大原因。1995年，约有16万结直肠癌新病例，其中6万人死于该疾病。在了解病因和改善这种疾病的治疗方面取得进展的要求之一是发展新的动物模型，在这些模型中可以研究正常组织生物学和癌变的所有阶段。这些工具已经到位，可以为癌症研究准备新的小鼠模型；我们需要的是基础和临床研究人员之间就人类肿瘤的分子生物学、它们的起源和进展以及实验室小鼠的生物学相关性和建模进行对话。为此，Jackson实验室建立了一系列用于研究人类癌症的小鼠模型的年会和合作研讨会，其总体目标是讨论临床前小鼠模型的开发和验证及其在转化性癌症研究中的应用。该系列旨在支持NCI于1998年7月29日发布的“人类癌症小鼠模型联盟”（MMHCC） RFA CA-98-013。第一次会议于1999年10月举行，重点关注乳腺癌的发生，其具体目标是：1)评估目前开发乳腺癌小鼠模型的方法；2)它们在开发预防或治疗人类乳腺癌的新治疗方法中的潜在应用。第二次会议将于2000年10月26日至29日在杰克逊实验室举行，紧接着是一个名为“在小鼠中模拟人类癌症的技术”的研讨会，重点是结肠直肠癌。活跃的研究人员和来自世界各地的学生将有机会分享想法，建立新的合作关系，讨论目前的进展，并规划肠上皮及其肿瘤的生物学分析的未来方向。本次会议和该系列其他会议的会议记录将在万维网上提供。

Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in the laboratory mouse. To this end, The Jackson Laboratory has established a series of annual meetings and companion workshops on mouse models for studying human cancer with the overall goal of discussing the development and validation of preclinical mouse models and their use in translational cancer research. This series is designed to support the "Mouse Models of Human Cancer Consortium" (MMHCC) RFA CA-98-013 released by NCI on July 29, 1998. The first meeting, held in October of 1999, focused on mammary carcinogenesis with the specific objective of: 1) evaluating current approaches to the development of mouse models of mammary cancer and 2) their potential application to the development of novel therapeutic approaches to preventing or otherwise treating breast cancer in humans. The second of these meetings will be held at The Jackson Laboratory on October 26-29, 2000 immediately following a companion workshop entitled "Techniques for Modeling Human Cancer in Mice" and will focus on colorectal cancer. Active investigators and students from around the world will have an opportunity to share ideas, establish new collaborations, discuss current progress and chart future directions in the biological analysis of the intestinal epithelium and its neoplasms. Proceedings from this and other meetings in the series will be made available on the World Wide Web.