Organic Synthesis on the Lab-scale in Flow - Sub project 2: Heterocycle Chemistry

传统上，开发一种新的有机合成路线的第一阶段研究通常在经典的圆底烧瓶中进行。然而，这种方法有许多缺点，例如在传质和传热方面的限制，以及处理危险试剂或活性中间体的能力。在这些方面，流动连续合成提供了一种很有前途的替代方案。然而，这样的系统仍然缺乏最佳实践。该项目将致力于开发从毫克到克级的连续流动模式的有效有机合成路线。特别是，这个项目将专注于开发合成具有明确取代模式的杂环的新方法。

Traditionally, the first stages of research for developing a novel organic synthetic route typically take place in classical round bottom flasks. However, this approach has a number of shortfalls, such as limitations in mass and heat transfer, and ability to handle hazardous reagents or reactive intermediates. In these respects, continuous synthesis in flow offers a promising alternative. However, best practice is still lacking with such systems. This project will aim to develop effective organic synthetic routes on a continuous flow paradigm, from a milligram to gram scale. In particular, this project will focus on developing novel routes to synthesizing heterocycles with well-defined substitution patterns.