Multidisciplinary characterisation of an orphan cell membrane complex in lung cancer

项目Aims1。在一个大型肺癌队列中，使用分子病理学来表征一种新的膜复合物，确定其与肿瘤参数和临床细节的关联。通过探索其生化特征并首次将其“可视化”，使该复合体中的癌症突变合理化。补充病理和生物物理分析，并测试从这些方法产生的新假设，体外肿瘤细胞模型。

Project Aims1. To use molecular pathology to characterise a novel membrane complex in a large lung cancer cohort, identifying associations with tumour parameters and clinical details.2. To rationalise cancer mutations in this complex by exploring its biochemical characteristics and 'visualising' it for the first time.3. To complement pathology and biophysical analyses, and to test new hypotheses generated from those approaches, with in vitro tumour cell models.