EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION

描述（由申请人提供）： J.大卫Gladstone研究所是一家非营利性生物医学研究机构，隶属于加州大学弗朗西斯科分校（UCSF）。 它由三个研究所组成，每个研究所都专注于一个重要的医学问题：心血管疾病、艾滋病毒和艾滋病以及神经退行性疾病，包括阿尔茨海默病。 格拉德斯通的所有教职员工都在UCSF担任学术职务，并从外部来源获得大部分实验室资金，主要是美国国立卫生研究院（NIH）。 Gladstone高度互动的多学科方法的成功反映在其23年历史中的1，200多份研究出版物和校外资金水平上。 在过去的二十年里，人类疾病的创新啮齿动物模型一直是格莱斯顿研究计划的核心组成部分。 小鼠模型越来越多地用于疾病导向的基础研究，导致迫切需要扩大和加强动物饲养和相关的核心设施。 为了满足这一需求，Gladstone正在建造新的实验室（200，000平方米）。（英尺）在加州大学旧金山分校的使命湾校区，包括国家的最先进的动物设施。 要求为新的动物设施提供固定设备（通风笼、笼清洗机、高压灭菌器和其他设备）的资金。 还要求为动物生物安全3级实验室的固定设备提供资金，该实验室将使用新的遗传小鼠模型来研究炭疽和其他传染媒介。 最后，还要求提供资金，以装备行为核心实验室，这对于确定人类疾病小鼠模型的特征至关重要。

DESCRIPTION (provided by applicant): The J. David Gladstone Institutes is a nonprofit, biomedical research organization affiliated with the University of California, San Francisco (UCSF). It is composed of three institutes, each focusing on an important medical problem: cardiovascular disease, HIV and AIDS, and neurodegenerative disorders, including Alzheimer's disease. All Gladstone faculty members hold academic appointments at UCSF and secure the majority of their laboratory funding from outside sources, primarily the National Institutes of Health (NIH). The success of Gladstone's highly interactive multidisciplinary approach is reflected by more than 1,200 research publications in its 23 years of history and by the level of extramural funding. Innovative rodent models of human disease have been a central component of Gladstone's research programs during the past two decades. The increasing use of mouse models for disease-oriented basic research has resulted in an urgent need to expand and enhance animal housing and associated core facilities. To meet this need, Gladstone is building new laboratories (200,000 sq. ft.) at UCSF's Mission Bay campus, including state-of-the- art animal facilities. Funds are requested for fixed equipment (ventilated cages, cage washers, autoclaves, and other equipment) for the new animal facility. Funds are also requested for fixed equipment in an Animal Biosafety Level 3 (ABSL3) laboratory in which novel genetic mouse models will be used for investigations of anthrax and other infectious agents. Finally, funds are requested to equip a Behavioral Core Laboratory, which is essential for characterizing mouse models of human disease.