GENERAL CLINICAL RESEARCH CENTER

阿肯色大学医学科学（UAMS）是阿肯色州唯一的医学院和三级保健中心，在过去十年中，在临床研究的资金和机构承诺方面经历了显着的扩张。小石城退伍军人管理医疗中心（VAMC）和阿肯色州儿童医院（ACH）是小石城退伍军人管理医疗中心的两个姊妹机构。在UAMS进行的临床研究数量现已达到临界质量，需要扩大和加强机构能力和基础设施，以维持高质量的临床研究。拟议中的综合临床研究中心（GCRC）将成为组成UAMS校园及其附属机构的多个研究要素的核心设施。长期目标是强调GCRC的资源，以招募对以患者为导向的研究感兴趣的教师；鼓励受资助的研究人员将研究结果从实验室应用到临床；培训初级研究人员进行临床研究；并向医务人员、医学、护理和基础科学专业的学生介绍和鼓励以病人为导向的研究。在UAMS医学院的大力支持下，一个广泛的培训项目将为这些目标提供保障。该提案特别寻求在VAMC建立一个GCRC，作为临床研究的载体，涉及由NIH和va资助的临床医生治疗的患者和门诊患者。因为营养和肥胖研究是单个项目的重要主题，代谢厨房、营养师支持和身体成分核心设施是拟议的GCRC的关键组成部分。还要求资助样品处理和肌肉分析核心。住院设施将容纳长期运动和营养平衡、基因治疗和睡眠研究的研究。住院病人和门诊病人的研究都将使用手术室进行代谢研究和输液。门诊室将用于大型遗传流行病学研究、家庭研究、受试者招募和简单筛查试验。一个拟议的计算机数据系统管理单位将为样本跟踪、病人调度、数据库管理和统计分析提供最先进的支持。生物统计学家将协助研究人员设计临床研究和分析数据。综合起来，通过GCRC提供的资源将维持和改善UAMS和VAMC的临床研究工作。

The University of Arkansas for Medical Sciences (UAMS), Arkansas's only medical school and tertiary care center, has undergone remarkable expansion in funding and institutional commitment to clinical research during the past decade. The biomedical research mission of UAMS is closely aligned with two sister institutions, the Little Rock Veterans Administration Medical Center (VAMC) and the Arkansas Children's Hospital (ACH). The quantity of clinical research conducted at UAMS has now reached a critical mass that requires the expansion and strengthening of the institutional capabilities and infrastructure to sustain high-quality clinical research. The proposed General Clinical Research Center (GCRC) will be the core facility for the multiple research elements that comprise the UAMS campus and its affiliates. The long-term goals are to emphasize the resources of the GCRC to recruit faculty with primary interests in patient oriented research; to encourage funded investigators to apply findings from bench to bedside; to train junior investigators in the conduct of clinical research; and to introduce and encourage patient-oriented research to housestaff and medical, nursing, and basic-science students. A broad training program, with the committed support of the UAMS College of Medicine, will underwrite these goals. This proposal specifically seeks to establish a GCRC at the VAMC as a vehicle for clinical research involving patients and outpatients treated by NIH- and VA-funded clinicians Because nutrition and obesity research are strong themes in the individual projects, a metabolic kitchen, dietitian support, and body composition core facility are key components of the proposed GCRC. Funding is also requested for sample processing and muscle analysis cores. Inpatient facilities will accommodate studies in extended-stay exercise and nutritional balance, gene therapy, and sleep studies. Both inpatient and outpatient studies will use procedure rooms for metabolic studies and infusions. Outpatient rooms will be used for large genetic epidemiology studies, family studies, subject recruitment, and simple screening tests. A proposed computer data systems management unit will develop state-of-the-art support for sample tracking, patient scheduling, database management, and statistical analysis. Biostatisticians will assist investigators in designing clinical studies and analyzing data. Combined, the resources provided through the GCRC will sustain and improve the clinical research efforts at UAMS and the VAMC.