Construction Grant 8th Floor BRB

描述(由申请人提供)：在国家研究资源中心、国家卫生研究院、卫生与公众服务部的帮助下，以及根据美国复苏法案有限竞争：校外研究设施改善计划(C06)授予的资金，马里兰大学巴尔的摩医学院提议翻新弗兰克·C·布雷斯勒研究大楼(BRB)八楼20,000平方英尺的实验室、办公室和会议研究空间，用于Marlene和Stewart Greenebaum癌症中心(UMGCC)。目前，BRB八楼的设施和设备明显过时，无法支持前沿的癌症研究。来自实验治疗学、激素反应性癌症以及分子和结构生物学(MSB)项目的UMGCC研究人员目前占据了BRB的9层和10层。拟议翻修的目标是整合MSB计划中的基础研究人员的一个有重点的互动小组，他们在细胞应激反应、结构生物学和基于结构的药物设计领域分享重叠的研究兴趣。 研究空间的共用将促进在最先进的研究空间中巩固来自MSB计划的主要合作研究人员，从而促进该小组之间以及与伦敦大学洛杉矶分校9楼和10楼的其他UMGCC调查人员之间的现有和新的互动。这些调查人员的接近还将加强与UMGCC共享服务的互动和利用，包括拟议的高通量筛选实验室。因此，我们预计新装修的空间的可用性将极大地提高UMGCC的能力，通过促进多学科的癌症转化研究，满足国家对癌症患者新的、毒性较低的治疗方法的需求。UMB SOM预计，通过将可持续方法纳入到此次翻修的设计和施工中，该项目将被认证为利兹银牌项目。此外，在这个项目的过程中，将创造大约120个新的美国就业机会，并将保持8至12个否则将被消除的就业机会。等待批准和材料交付该项目最早可于2009年12月开始，至2011年8月完成。

DESCRIPTION (provided by applicant): With the assistance of the National Center of Research Resources, National Institutes of Health, Department of Health and Human Services and funds awarded under the American Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06), the University of Maryland Baltimore School of Medicine proposes to renovate 20,000 gross square feet of lab, office, and conference research space on the eighth floor of the Frank C. Bressler Research Building (BRB) for the Marlene and Stewart Greenebaum Cancer Center (UMGCC). At the present time, the facilities and equipment on the eighth floor of BRB are significantly outdated and unable to support cutting-edge cancer research. UMGCC investigators from the Experimental Therapeutics, Hormone Responsive Cancers, and Molecular and Structural Biology (MSB) Programs currently occupy the 9th and 10th floors of BRB. The goal of the proposed renovation is to consolidate a focused interactive group of basic investigators in the MSB Program who share overlapping research interests in the area of cellular stress responses, structural biology, and structure-based drug design. The co-location of research space will promote consolidate key collaborating investigators from the MSB Program in state-of-the art research space, thereby promoting existing and new interactions among this group and with other UMGCC investigators on the 9th and 10th floors of BRB. The proximity of these investigators will also enhance interactions with and utilization of UMGCC Shared Services, including the proposed High-Throughput Screening Lab. Thus, we envision the availability of newly renovated space will dramatically enhance UMGCC's abilities to address the unmet national need for novel and less toxic therapies for cancer patients by promoting multidisciplinary translational cancer research. The UMB SOM anticipates this project will be certified as a LEEDS silver project by incorporating sustainable methods in the design and construction of this renovation. Furthermore, approximately 120 new American jobs will be created over the course of this project and between 8 and 12 jobs will be maintained that otherwise will be eliminated. Pending approvals, and delivery of materials this project can begin as early as December 2009 and be completed by August 2011.