Rat Genome Database

描述（由申请人提供）：在过去的三年中，大鼠作为人类疾病的生理模型生物体和经证实的人类疾病研究的基于基因组的模型的地位有所提高。 主流化和逐步改进RGD的必要性对于为科学界的研究提供集中的、综合的基因组和遗传数据资源至关重要。 这个经过验证的系统化数据库涵盖了基因组和遗传资源的广度，为美国的大鼠模型研究和需要大鼠生物学知识的研究人员提供了知识基础，以指导人类疾病的研究。 在此，我们概述了通过开发、测试和实施促进生物信息学和支持活动来支持获取大鼠基因组序列的倡议。 该计划旨在为RGD用户提供一致的基因组和物理注释，视图和草图以及完成或部分完成的大鼠基因组的地图。 这包括维护和改进RGD，以满足研究界日益增长的需求。 它旨在改进文献数据采集方法，加强严格的质量和命名控制，并改善生物学描述性信息。 新工具的开发将继续加快主要大鼠基因组和生物学项目数据的使用，以及跨物种比较。 注释的大鼠基因组文库将被并入以支持基因微阵列表达、通路和蛋白质组学分析到RGD中。将扩大区域基因组数据基础设施和基线服务，以更有效地获取、管理和整合新出现的大鼠基因组、遗传和其他生物数据。 这将通过创建和支持专业“门户网站”来实现，以整合社区重点疾病和专业数据。RGD将与基因本体论联盟、小鼠基因组数据库和国家生物技术信息中心保持合作，以扩展基因、表型和疾病本体论。 最后，RGD将通过社区研讨会和演示、改进的在线和用户响应帮助服务、新的教育“门户”和增强的访问科学家计划和合作活动，增加和加强我们的用户支持。 这些拟议的活动使我们能够更好地服务于大鼠研究界的需求，并为更广泛的科学界提供查找，分析和利用大鼠数据的能力，以促进他们的研究。

DESCRIPTION (provided by applicant): The past three years has seen an enhancement in the status of the rat as a physiological model organism for human disorders and a proven genome-based model for human disease research. The need for mainstream and progressive improvement of RGD is essential to provide the scientific community a centralized, integrated resource of genomic and genetic data for their research. This proven repository of systematically curated data, spanning the breadth of genomic and genetic resources, provides a knowledge base for rat model research in the U.S. and for investigators needing biological knowledge of the rat to guide research in human disease. Herein, we outline the initiative that will support access to the rat genomic sequence through the development, testing and implementation of facilitating bioinformatics and supporting activities. The initiative is aimed at providing consistent RGD user access to genomic and physical annotations, views, and maps of the draft and finished or partially finished rat genome. This includes maintenance and improvements to RGD to meet the growing needs of the research community. It is directed towards improving methods of data acquisition from the literature, enhancing stringent quality and nomenclature control, and improving biologically descriptive information. Novel tool development will continue to expedite the use of data from major rat genome and biology projects, as well as cross species comparisons. Annotated rat genomic libraries will be incorporated to support the analysis of gene microarray expression, pathway and proteomics into RGD. RGD infrastructure and baseline services will be expanded to more efficiently acquire, curate and integrate emerging rat genomic, genetic and other biological data. This will be achieved by creating and supporting specialty "portals" to integrate community focused disease and specialty data. RGD will maintain collaborations with the Gene Ontology Consortium, Mouse Genome Database and National Center for Biotechnology Information to expand gene, phenotype and disease ontology. Finally, RGD will increase and strengthen our user support through community workshops and presentations, improved online and user response help services, a new educational "portal" and enhanced Visiting Scientist Program and collaborative activities. These proposed activities allow us to better serve the rat research community's needs and provide the wider scientific community with the ability to find, analyze and exploit rat-based data to promote their research.