Evaluation of Vestibular Function in Meniere's Disease

描述：(申请人提供) 这项拟议的研究的目的是了解糖尿病的病理生理学 梅尼埃病的前庭功能障碍及其治疗。这个 对前庭功能的特异性影响(定性和定量) 梅尼埃病本身和鼓室内注射庆大霉素都用于缓解 眩晕是未知的，将在拟议的研究中确定。这个 研究策略是分析三种情况下的前庭眼反射(VOR) 从激活半规管或刺激的刺激反应的维度 耳石。前庭功能也将通过测量以下指标进行评估 主观视觉垂直和前庭诱发的肌源性电位。 由高频、高加速度头部推力引起的角度VOR将 进行研究，以确定梅尼埃病的影响和 鼓室内注射庆大霉素对单个半规管功能的影响。这个 这些患者的翻译性VOR将根据以下反应进行评估 头部快速横向平移。通过与 前庭功能正常的受试者和已知手术的受试者 单侧前庭破坏(UVD)，这些研究将提供一种新的 了解梅尼埃病本身的影响，以及梅尼埃病的影响 用庆大霉素治疗单个前庭末梢器官。 鼓室内注射庆大霉素和外科UVD后VOR的恢复 通过对眼速轨迹的分析进行评估。这个 矫正眼球运动，减少凝视错误的发生 前庭功能减退对高位反应的影响 还将分析加速度、角度和平移头部运动。 这项研究得出的信息将对 前庭测试在梅尼埃病中最有用，在决定何时和 用什么来治疗梅尼埃病患者。

DESCRIPTION:(provided by applicant) The objective of the proposed research is to understand the pathophysiology of the vestibular disturbances in Meniere's disease and how to treat them. The specific effects (both qualitative and quantitative) on vestibular function of both Meniere's disease itself and of intratympanic gentamicin used to alleviate vertigo are unknown and will be determined in the proposed research. The research strategy is to analyze the vestibuloocular reflex (VOR) in three dimensions from responses to stimuli that activate the semicircular canals or the otoliths. Vestibular function will also be evaluated from measurements of the subjective visual vertical and from vestibular-evoked myogenic potentials. The angular VOR evoked by high-frequency, high-acceleration head thrusts will be studied in order to determine the effects of Meniere's disease and of intratympanic gentamicin on the function of individual semicircular canals. The translational VOR in these patients will be evaluated from the responses to rapid, lateral translations of the head. Through comparisons with findings in subjects with normal vestibular function and those with known surgical unilateral vestibular destruction (UVD), these studies will provide a new understanding of the effects of Meniere's disease itself, and the effects of treatment with gentamicin, on individual vestibular end organs. Recovery of the VOR after intratympanic gentamicin and after surgical UVD will be assessed through analyses of the trajectories of eye velocity. The corrective eye movements that reduce the gaze errors that occur as a consequence of diminished vestibular function in the responses to high acceleration angular and translational head movements will also be analyzed. The information derived from this research will have practical import on which vestibular tests are most useful in Meniere's disease, and on deciding when and with what to treat patients with Meniere's disease.