Molecular Mechs.Regulating Cancer Cell Proliferation

描述(申请人提供)：这个博士后培训项目名为“调控癌细胞增殖的分子机制”，由来自威斯康星大学麦迪逊分校10个系的22名科学家组成，他们对癌细胞生物学有普遍的兴趣，对维持肿瘤细胞增殖的分子有特殊的兴趣。请拨经费用于六个培训职位。该计划的目标是在与癌症生物学的这一方面相关的问题和技术方面培训博士、医学博士和医学博士级别的科学家，以便他们能够成为拥有自己的研究计划的独立研究人员。在完成培训计划后，这些科学家应该能够竞争学术、政府或企业生物医学研究部门的最佳职位。受过调节分子分析的研究人员，包括生长因子、生长因子受体、原癌基因、转录因子和细胞外基质中的分子，可能会进行影响我们对癌症病因的理解的研究，并建立对特定肿瘤的分子检测和诊断有用的系统。 培训方案旨在为每个受训者提供一名主要导师(培训员)，受训者将在其实验室接受与导师实验室研究相关的具体问题和技术的指导。受训者将参与研究工作，并应对研究进展做出具体贡献，研究进展将提交给同行评议的期刊发表。此外，培训计划通过强制参加计划活动，为受训者提供了更广泛的接触肿瘤细胞生物学实验方法和这些方法的临床应用的机会。最后，每个受训人员在其研究和方案其他活动中的进展情况将由方案主任和方案中的四名高级培训人员组成的评估委员会每年进行评估。这项评估将通过口头和书面评估为学员提供建设性的批评。评估委员会的成员将努力帮助导师为受训人员提供尽可能好的准备，使他们能够独立从事癌症研究。

DESCRIPTION (provided by applicant): This Postdoctoral Training Program, "Molecular Mechanisms Regulating Cancer Cell Proliferation," consists of 22 scientists from 10 departments at the University of Wisconsin-Madison who have a general interest in cancer cell biology and specific interests in the molecules that maintain the proliferation of neoplastic cells. Funds are requested for six training positions. The goal of this program is to train Ph.D.-, D.V.M.- and M.D.-level scientists in the questions and techniques relevant to this aspect of cancer biology so that they can become independent researchers with their own research programs. Upon completion of the training program, these scientists should be able to compete for the best positions in academic, government, or corporate biomedical research departments. Investigators trained in the analysis of regulatory molecules, including growth factors, growth factor receptors, proto-oncogenes, transcription factors, and molecules in the extracellular matrix, may pursue research that will affect our understanding of cancer etiology and establish systems useful in the molecular detection and diagnosis of specific tumors. The training program is designed to provide each trainee with a primary mentor (trainer) in whose laboratory the trainee will be instructed in the specific questions and techniques relevant to the research of the mentor's laboratory. The trainee will participate in the research effort and should make specific contributions to the research progress, which will be submitted to peer-reviewed journals for publication. In addition, the training program provides to the trainees a broader exposure to experimental approaches in tumor cell biology and to the clinical application of these approaches through mandatory participation in the program activities. Finally, the progress of each trainee in his or her research and in the other activities of the program will be evaluated annually by an Evaluation Committee made up of the Program Director and four senior trainers in the program. This evaluation will provide the trainee with constructive criticism through oral and written evaluations. The members of the Evaluation Committee will strive to help the mentors provide the trainees with the best possible preparation for independent careers in cancer research.