SPORE in Skin Cancer

在这项提案中，我们寻求在新配置的Dana Farber哈佛癌症中心内，在哈佛大学和布里格姆妇女医院建立一个专门的皮肤癌卓越研究计划(孢子)。达纳-法伯哈佛癌症中心孢子包括来自哈佛医学院和公共卫生学院的研究人员，以及布里格姆和妇女医院、贝丝以色列女执事医疗中心、儿童医院医疗中心、达纳-法伯癌症研究所和马萨诸塞州总医院的研究人员。这些机构围绕黑色素瘤和皮肤肿瘤学的转化研究这一主题走到了一起，提出了五个项目、五个共享资源(CORE)、一个发展计划和一个癌症发展计划。项目1将把流行病学发现转化为改进的黑色素瘤风险模型的开发；一旦开发完成，这些模型将在大量患者群体中得到验证。项目2利用全基因组转录图谱的力量，最终目标是提高我们诊断和预测原发黑色素瘤生物学过程的能力。项目3测试了这样一种假设，即皮肤T细胞淋巴瘤是一组记忆T细胞的恶性肿瘤，通常对皮肤进行免疫监控，并寻求确定新的治疗靶点。项目4和项目5是激动人心的转化性临床试验。在项目4中，使用新的免疫学终点，直接比较了两种截然不同的树突状细胞疫苗接种策略。在项目5中，生物化疗方法被用于治疗转移性黑色素瘤。将再次进行免疫学监测，目标是改善黑色素瘤患者的治疗。这五个项目由五个核心整合在一起。生物统计核心为每项研究提供专家咨询，而组织和病理学核心提供对这些项目至关重要的组织的有控制和有组织的访问。对免疫终点的评估。临床数据管理核心提供了一项至关重要的服务，即创建动态和灵活的数据库，将多个哈佛附属医院的项目整合在一起。最后，一个发展计划有五个项目，每个项目都有可能演变成一个完整的项目，并取得了有希望的翻译结果。职业发展计划是这项申请的核心部分，它着眼于内科科学家在职业生涯中的发展。已经建立了一个行政结构，确保监督、整合、规划、教学活动，最重要的是，如果取得有希望的翻译结果，则确保成长和演变为一个完整的项目。职业发展计划是这项申请的核心部分，它着眼于内科科学家在职业生涯中的发展。已经建立了一个行政结构，确保监督、整合、规划、教学活动，最重要的是，确保孢子在未来五年的生长和演变。

In this proposal, we seek to establish a Specialized Program of Research Excellence (SPORE) in Skin Cancer at Harvard University and Brigham and Women's Hospital, within the newly configured Dana Farber Harvard Cancer Center. The Dana-Farber Harvard Cancer Center SPORE includes investigators from Harvard Medical School and School of Public Health, as well as the Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Children's Hospital Medical Center, Dana- Farber Cancer Institute, and the Massachusetts General Hospital. These institutions have come together around the theme of translational research in melanoma and cutaneous oncology Five Projects, five Shared Resources (Cores), a Developmental Program, and a Cancer Development Program are proposed. Project 1 will translate epidemiologic findings into the Development of improved risk models for melanoma; once developed, these will be validated across a large patient population. Project 2 employs the power of whole genome transcriptional profiling with the ultimate goal of improving our ability to diagnose and predict the biological course of primary melanoma. Project 3 tests the hypothesis that cutaneous T cell lymphoma is a malignancy of a population of memory T cells that normally performs immunosurveillance of the skin, and seeks to identify new targets for therapy. Projects 4 and 5 are exciting translational clinical trials. In Project 4, two diametrically different dendritic cell vaccination strategies are directly compared, using novel immunological endpoints.. In Project 5, biochemotherapeutic approaches are employed to treat metastatic melanoma. Immunologic monitoring will be performed again with the goal of improving therapy for melanoma patients. These five Projects are integrated by five Cores. The Biostatistics Core provides expert consultation to each study while the Tissue and Pathology Core provides controlled and organized access to tissue vital for these projects. An assessment of immunologic endpoints. The Clinical Data Management Core provides a vital service of creating dynamic and flexible databases that integrate Projects across multiple Harvard-affiliated hospitals. Finally, a Development Program features five projects, each of which is a candidate for evolution into a full project is promising translational results are obtained. A Career Development Program, which takes a broad view of the development of the physician scientist over the course of a career, is a centerpiece of this application. An administrative structure is in place that will assure oversight, integration, planning, didactic activities, and most importantly, the growth and evolution into a full project if promising translational results are obtained. A Career Development Program, which takes a broad view of the development of the physician scientist over the course of a career, is a centerpiece of this application. An administrative structure is in place that will assure oversight, integration, planning, didactic activities, and most importantly, the growth and evolution of the SPORE over the next five years.