Establishment and maintenance of T cell memory

保护性记忆T细胞免疫应答通过快速诱导杀伤T细胞来保护我们的身体免受病原体的侵害。这可以保护我们免受严重甚至致命的疾病。我们的工作将为身体如何制造这些有效的“步行者”提供见解。这项工作将对确定如何操纵这些免疫细胞以预防和治疗致病性和自身免疫性疾病以及优化疫苗接种方法具有重要意义。

Protective memory T cell immune responses defend our body against pathogens by the rapid induction of killer T cells. This protects us from severe or perhaps even fatal disease. Our work will provide insights to how the body makes these potent ‘footsoldiers’. This work will have important implications for identifying how these immune cells can be manipulated to prevent and treat pathogenic and autoimmune disease and for optimising approaches to vaccination.