Modelling heat impact on human hard and soft tissue in pulsed laser ablation

"这是一个机械工程博士研究项目，特别是组织生物力学。背景：癌症或肌肉骨骼疾病影响着全世界老龄化社会的数百万人。现代治疗策略，特别是在转移前阶段，通常采用切除术，这是使用微创进入程序进行。基于激光消融的切割被认为是一种"冷"过程，对周围组织的影响最小。同样，激光消融用于制备微米尺寸的活检组织，这反过来又为临床前研究中新治疗技术的开发提供了信息。然而，很少有人知道在消融过程中对材料的热影响的各种组织，可能是潜在的treated.Project：因此，本项目旨在开发一种技术，允许调查的热影响在脉冲激光消融过程中对不同的组织，具体到临床和临床前的应用。一个例子可以是肝转移瘤或脑肿瘤治疗的激光消融。主要任务包括：（i）开发模拟套件，例如有限元，以评估基于骨细胞外基质的初始工作的脉冲激光消融对不同硬组织和软组织的热影响，（ii）验证和确认模拟套件，（iii）使用该模拟套件确定临床和临床前挑战中不损伤周围材料的可接受操作参数。影响：如果成功，该项目将对微创手术技术产生直接，积极的影响。此外，研究结果将影响微机械测试的最新制备策略。"

"This is a PhD research project in mechanical engineering, specifically tissue biomechanics.Background: Cancer or musculoskeletal diseases affect millions of people in ageing societies worldwide. Modern treatment strategies, especially in pre-metastatic stages, often employ resections, which are carried out using minimal invasive access procedures. Laser ablation based dissection is supposed to be a "cold" process with minimal impact on the surrounding tissue. Likewise, laser ablation is used to prepare micron-sized biopsies that, in turn, inform the development of new treatment technologies in preclinical research. However, little is known about the heat impact on the material during the ablation process for the diverse range of tissues that may be potentially treated.Project: Therefore, this project aims at developing a technology that allows to investigating the heat impact during pulsed laser ablation on different tissues specific to clinical and pre-clinical application. An example could be laser ablation of liver metastases or brain tumour treatment. Key tasks include:(i) develop a simulation suite, e.g. finite elements, to evaluate the heat impact of pulsed laser ablation on different hard and soft tissue based on initial work on bones extra-cellular matrix,(ii) verify and validate the simulation suite, (iii) use this simulation suite to identify a admissible operating parameters that do not damage surrounding material for clinical and pre-clinical challenges.Impact: If successful, this project will have a direct, positive impact on minimal invasive surgery technologies. In addition, the results will impact state of the art preparation strategies for micromechanical testing."