Translational Breast Cancer Research Training Program

描述（由申请人提供）：女性结局的改善 乳腺癌将需要一个新兴的研究人员， 翻译研究员科学家在两个基本领域都有坚实的基础， 分子和细胞研究谁也有临床的理解， 疾病将指导乳腺癌研究的最有效的未来。等 调查人员被称为“翻译”，因为他们的能力， 将基本发现转化为临床策略。这类培训 既需要一个资金充足的核心调查人员进行基础实验室， 研究和优秀的临床培训计划。在贝勒大学 医学方面，最近成立的乳房中心提供了这样一个组合。 在这个应用程序中，到第三年，我们建议支持12个博士学位。或者医学博士 博士后研究生。所有的受训者都将致力于乳腺癌的一个方面 选自激素作用和治疗应用，生长因子， 信号转导，细胞周期调控，正常乳腺发育，乳腺 癌症预防、乳腺癌演变、分子遗传学或基因 疗法涵盖科学写作和研究的正式教学课程 赠款、生物统计学、临床乳腺癌问题和组织病理学 乳腺癌发展的证据工作的进展和方向 学员的研究项目将在每两周的数据中得到密切监测 评论.学员还将参加每周一次的临床乳腺癌病例 会议，以增加他们对临床问题的理解。 由于我们的综合性质，以及医学博士的平衡包容。和 博士导师，学员将有丰富的机会与 他们的临床同行讨论翻译问题。因此，由 提供一个程序，涉及实验室培训的指导下， 有着长期乳腺癌治疗记录的知名导师 研究，与成功的医生科学家的互动，以及接触 临床乳腺癌问题，我们将创造一个独特的机会， 培养新的翻译研究人员。

DESCRIPTION (provided by applicant): Improvements in the outcome for women with breast cancer will require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in both basic molecular and cellular research who also have an understanding of the clinical disease will direct the most effective future of breast cancer research. Such investigators have been called "translational" because of their ability to translate basic findings into clinical strategies. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the recently established Breast Center affords such a combination. In this application, by the third year, we propose to support 12 Ph.D. or M.D. postdoctoral trainees. All trainees will work on an aspect of breast cancer chosen from hormone action and therapeutic applications, growth factors, signal transduction, cell cycle control, normal breast development, breast cancer prevention, breast cancer evolution, molecular genetics, or gene therapy. Formal didactic courses covering scientific writing and research grants, biostatistics, problems in clinical breast cancer, and histopathology of breast cancer evolution will be required. Progress and direction of the trainee's research project will be closely monitored in bi-weekly data reviews. Trainees will also attend a weekly clinical breast cancer case conference in order to increase their understanding of clinical issues. Because of our integrative nature, and the balanced inclusion of M.D. and Ph.D. mentors, the trainees will have abundant opportunities to interact with their clinical counterparts for discussion of translational issues. Thus, by providing a program that involves laboratory training under the direction of well-established mentors with a long-standing track record of breast cancer research, interaction with successful physician-scientists, and exposure to clinical breast cancer issues, we will have created a unique opportunity to train new translational researchers.