Translational Breast Cancer Research Training Program

转化乳腺癌研究培训计划

基本信息

批准号：
10475088
负责人：
Suzanne AW Fuqua
金额：
$ 19.36万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475088
关键词：
Research Training Training Programs malignant breast neoplasm

项目摘要

Abstract Improvements in the outcome for women with breast cancer require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in basic molecular and cellular research who also have an understanding of the clinical disease course will direct the most effective future of breast cancer research. Such investigators have been called “translational” because of their ability to translate basic findings into clinical strategies and vice versa. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the Breast Center affords such a combination. This is a new application for a formal Training Program that began in 1999 when what is now the Smith Breast Center was formed. All trainees work on a focused aspect of breast cancer research including 1)Hormone Action/Endocrine Therapy 2)Molecular Genomics 3)Growth Factors/Signal Transduction 4)Normal Breast Development/Breast Cancer Prevention and 5)Novel Treatment Strategies. Formal didactic courses covering Scientific writing, research grants, Biostatistics, Leadership skills, Molecular carcinogenesis, and problems in clinical translational breast cancer research are required. Progress and direction of the trainee's research project are closely monitored in bimonthly Research and Development workshops.

抽象的乳腺癌女性的结果改善需要新的新品种研究人员，翻译研究人员。基础分子的基础很强的科学家以及对临床疾病病程也了解的蜂窝研究将指导乳腺癌研究最有效的未来。这些调查人员被称为 “翻译”是因为它们能够将基本发现转化为临床策略和副 Versa。这种类型的培训需要提供基本的调查人员资金良好的核心实验室研究和出色的临床培训计划。在贝勒医学院乳房中心提供了这样的组合。这是进行正规培训的新应用该计划始于1999年，当时现在是史密斯乳房中心。所有学员在乳腺癌研究的重点方面工作，包括1）激素作用/内分泌治疗2）分子基因组学3）生长因子/信号转导4）正常乳房发育/乳腺癌预防和5）新型治疗策略。正式的涵盖科学写作，研究补助，生物统计学，领导技能，分子癌变和临床翻译乳腺癌研究的问题是必需的。密切监视学员研究项目的进度和方向两次研发研讨会。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance.

DOI：
10.2174/1389557520666200103114556
发表时间：
2020
期刊：
MINI-REVIEWS IN MEDICINAL CHEMISTRY
影响因子：
3.8
作者：
Ghosal, Kajal;Agatemor, Christian;Han, Richard, I;Ku, Amy T.;Thomas, Sabu;Mukherjee, Sudit
通讯作者：
Mukherjee, Sudit

Avoiding Extinction: Cancer-Associated Fibroblasts Help Triple-Negative Breast Cancer Outrun Chemotherapy.

避免灭绝：癌症相关成纤维细胞帮助三阴性乳腺癌战胜化疗。