UT Gastroenterology/Hepatology Research Training Program

描述（由申请人提供）： UT胃肠病学/肝病学研究培训计划的培训需要 放置在消化和肝脏疾病部门的实验室中， 在几个基础科学部门的实验室里， 德克萨斯西南医学中心和达拉斯退伍军人事务医疗中心 中心校区。在约翰·M博士的指导下，作者：Stuart J. Spechler和Dobel L. Thiele，申请人经过仔细筛选， 受访每一位成功的申请者将承担一个主要的研究项目 在一名或多名成员的直接监督下， 高级研究学院。此外，每名学员都将有近 与其他高级研究学院和各种成员的互动 基础科学部门。实验室正在进行的项目， 这些教员非常多样化，涉及各种各样的技术 在细胞和分子生物学中。代表性项目包括详细的 研究替代生化途径的性质， 胆汁酸的生物合成，孤儿核受体在控制中的作用 胆汁酸合成和固醇转运的新疗法分析， 丙型肝炎，细胞毒性淋巴细胞在肝炎等疾病中的作用 和炎症性肠病以及新描述的胆固醇的作用24 羟化酶和ABCA 1蛋白在胆汁胆固醇分泌中的作用。最初 所有学员都参加生物伦理表演的正式讲座 研究，并在全年参加定期研究会议 以及该部门的临床会议。此外，还有一个为期两年的 生理学、分子生物学和细胞生物学系列讲座 胃肠道的器官。在这两到四年里， 在紧张的研究工作过程中，学员将学会利用各种 分子和细胞生物学的基本实验程序。如果 受训者从事临床研究，他/她将参加一年 人类研究各个方面的长期正式课程。所有人的进步 对受训人员进行定期监测，在这一紧张时期结束时， 研究，每个受训者也将有机会完成他/她的 临床训练在医学上有使用动物的正式课程 研究和伦理人类调查的特殊问题。有 一个积极招募代表性不足的少数民族的项目。

DESCRIPTION (provided by applicant): Training in the UT Gastroenterology/Hepatology Research Training Program takes place in the laboratories of the Division of Digestive and Liver Diseases and in the laboratories of several basic science departments at The University of Texas Southwestern Medical Center and the Dallas Veteran's Affairs Medical Center campuses. Under the direction of Drs. John M. Dietschy, Stuart J. Spechler and Dwain L. Thiele, applicants are carefully screened and interviewed. Each successful applicant will undertake a major research project for two to four years under the direct supervision of one or more members of the Senior Research Faculty. In addition, each trainee will have close interactions with other Senior Research Faculty and with members of various basic science departments. The projects that are ongoing in the laboratories of these faculty members are very diverse and involve a wide variety of techniques in cellular and molecular biology. Representative projects include detailed studies into the nature of alternative biochemical pathways for the biosynthesis of bile acids, the role of orphan nuclear receptors in the control of bile acid synthesis and sterol transport, an analysis of new treatments for hepatitis C, the role of cytotoxic lymphocytes in diseases such as hepatitis and inflammatory bowel disease and the role of newly described cholesterol 24 hydroxylase and the ABCA1 protein in biliary cholesterol secretion. Initially all trainees attend formal lectures in the performance of ethical biological research and, throughout the year, participate in regular research conferences and clinical conferences in the division. In addition, there is a two-year cycle of lectures devoted to the physiology, molecular biology and cell biology of the organs of the gastrointestinal tract. Throughout this two to four year course of intense research work, the trainees will learn to utilize a variety of basic laboratory procedures common to molecular and cell biology. If the trainee is engaged in clinical investigation, he/she will participate in a year long formal course in various aspects of human research. The progress of all trainees is monitored on a regular basis and, at the end of this intense period of research, each trainee will also have the opportunity of completing his/her clinical training. There are formal courses in the use of animals in medical research and in the special problems of ethical human investigation. There is an active program for recruiting underrepresented minorities.