Mark I, Model 68A Cesium 137 Research Irradiator

描述(由申请者提供)：通过NIH的共享仪器资助计划，申请资金购买专为小鼠全身照射而设计的铯-137辐射器。主要的研究应用包括：1)移植前去除宿主骨髓；2)在T细胞活化和发育研究中照射抗原提呈细胞；3)电离辐射对特定突变的原癌基因作用的测试。这种铯-137辐照器将在以下特定领域使14名研究人员受益：B和T细胞的发展和TCR激活的研究；巨噬细胞介导的炎症和伤口愈合；红细胞生成和促红细胞生成素受体信号；以及原癌基因和病毒癌基因作用的分子机制，包括Friend病毒gp55、SF-StK、PPARb和Patched以及Piml的研究。

DESCRIPTION (provided by applicant): Via NIH's Shared Instrumentation Grant Program, funds are requested to purchase a Cesium-137 irradiator designed for the whole body irradiation of mice. Major research applications are 1) Ablation of host bone marrow prior to transplantation; 2) Irradiation of antigen presenting cells in studies of T cell activation and development; and 3) Tests of ionizing radiation on the action of specifically mutated proto-oncogenes. This Cesium-137 irradiator would benefit a users group of 14 investigators in the following specific areas: B and T cell development and studies of TCR activation; macrophage mediated inflammation and wound healing; erythropoiesis and erythropoietin receptor signaling; and molecular mechanisms of proto-oncogene and viral oncogene action, including studies of Friend virus gp55, Sf-Stk, PPARb and Patched, and Piml.