DOSE-RESPONSE TO EXERCISE IN WOMEN AGED 45-75 YEARS

老年妇女运动剂量反应的主要目标 45-75岁（DREW）是为了调查不同数量的 运动对心肺适能和心血管疾病风险因素的影响 疾病受试者将久坐不动，超重或肥胖，绝经后 患有正常高血压或I期高血压的女性，因此 患心血管疾病的风险较高。共有450名妇女（35 %将来自少数群体）将被随机分配到对照组 组（N=100）或3个运动组之一（N=150，最低运动剂量 在两个最高运动组中各100个）。被派往 运动组将在4、8或10个月的能量消耗下运动6个月。 每周12千卡/公斤。这些练习代表了公众的共识 最近出版的指南中关于身体活动的健康建议 来自美国公共卫生署、美国心脏协会和 美国运动医学院（8千卡/公斤每周）和剂量50 低于（每周4千卡/千克）50%以上（每周12千卡/千克） 共识剂量所有女性都将以最大摄氧量的50%进行锻炼。行使 课程将在实验室进行，每个课程都有单独的监督。 会议和严格控制频率，持续时间和强度。这将 提供完整的文件，记录完成的确切运动量。 主要结果指标为最大摄氧量和静息收缩压。其他 心血管疾病危险因素，心理社会变量，健康相关 生活质量、身体成分和脂肪分布是次要结果。 其他次要分析将重点关注观察到的 剂量-反应效应通过健康，种族， 风险因素或年龄。将在基线和6个月时进行评估。的 研究将提供关于（1）结果变化模式的信息 产生的每一个几个运动剂量，（2）是否执行运动， 低于目前的共识剂量有任何好处，（3）是否执行 更多的运动比共识剂量更大（或按比例更大） 健康益处，以及（4）久坐不动的女性的特征， 可能会从各种运动剂量中受益。

The primary goal of the Dose-Response to Exercise in Women Aged 45-75 Years (DREW) is to investigate the effects of different amounts of exercise on both cardiorespiratory fitness and risk factors for cardiovascular disease. Participants will be sedentary, overweight or obese, postmenopausal women who have high normal blood pressure or Stage I hypertension, and thus are at moderately high risk for cardiovascular disease. A total of 450 women (35 percent will be from minority groups) will be randomly assigned to a control group (N=100) or to 1 of 3 exercise groups (N=150 for the lowest exercise dose and 100 each in the two highest exercise groups). Women assigned to the exercise groups will exercise for 6 months at energy expenditures of 4, 8, or 12 kcal/kg per week. These exercises doses represent the consensus public health recommendation for physical activity from recently published guidelines from the U.S. Public Health Service, American Heart Association, and the American College of Sports Medicine (8 kcal/kg per week) and at doses 50 percent below (4 kcal/kg per week) 50 percent above (12 kcal/kg per week) the consensus dose. All women will exercise at 50 percent of VO2 max. The exercise sessions will take place in the laboratory, with individual supervision of each session and strict control of frequency, duration, and intensity. This will provide thorough documentation of the exact amount of exercise completed. Primary outcome measures are VO2 max and resting systolic blood pressure. Other cardiovascular disease risk factors, psychosocial variables, health-related quality of life, body composition, and fat distribution are secondary outcomes. Other secondary analyses will include a focus on the extent to which observed dose-response effects are modified by baseline levels of fitness, ethnicity, risk factors, or age. Assessments will take place at baseline and 6 months. The research will provide information about (1) patterns of change in outcomes produced by each of several exercise doses, (2) whether performing exercise at less than the current consensus dose has any benefit, (3) whether performing more exercise than the consensus dose has greater (or proportionally greater) health benefits, and (4) the characteristics of sedentary women who are most likely to benefit from various exercise doses.