CORE--MRI

通过磁共振（MR）进行的分子和细胞成像提供了对活组织中发生的生理、细胞和分子过程及其对医疗干预的响应的真实的体内分析。新的成像技术可以监测肿瘤体积、肿瘤血管通透性、细胞特异性生化标志物、蛋白质表达、肿瘤内药物浓度和代谢以及细胞募集的变化。新的目的 拟议的MRI设施是提供最先进的磁共振成像（MRI）的小动物和癌症患者，以支持UPCI成员的研究活动。该设施的具体目标是：（1）提供全面的最先进的MRI方法，以经济和全面的方式支持基础和临床科学工作。这些服务包括分子和细胞成像技术，通过提供脉冲序列设计和实施，成像协议开发，造影剂合成和数据分析包开发服务;（2）提供相关MRI方法设计和应用方面的适当专家咨询，以便UPCI成员能够明智地选择最适合他们研究的技术;（3）提供适当的仪器和技术，身体和智力技能来执行这些技术，使UPCI成员能够以方便和经济的方式利用有效和尖端的成像方法，包括脉冲序列设计和实施，成像协议开发，造影剂合成和数据分析包开发。在过去的一年里，UPCI招募了两名新的具有癌症成像专业知识的教师，同时，近年来匹兹堡大学和卡内基梅隆大学密切合作，在小动物和人类MRI系统上投入了大量资金。为这个新设施申请的资金将为具有技术专长的个人提供部分支持，购买用品，并提供成像时间，以便UPCI研究人员可以使用体内分子和细胞方法以最低的成本获得对癌症生理学，生物学和生物化学的新的非侵入性见解，这有望导致原发性和转移性肿瘤的准确诊断以及对癌症治疗反应的评估的进展。

Molecular and cellular imaging by magnetic resonance(MR) provides real time in vivo analyses of the physiological, cellular, and molecular processes that occur in living tissues and their responses to medical interventions. New imaging techniques can monitor changes in tumor volume, tumor vascular permeability, cell-specific biochemical markers, protein expression, intratumoral drug concentrations and metabolism, and cell recruitment. The purpose of the newly proposed MRI Facility is to provide state of the art MR imaging (MRI) of both small animals and cancer patients, to support research activities of UPCI members. The specific aims of the Facility are: (1) Provide comprehensive state of the art MRI methods, to support both basic and clinical scientific efforts in an economic and comprehensive fashion. These services include molecular and cellular imaging techniques, by supplying pulse sequence design and implementation, imaging protocol development, contrast agent synthesis, and data analyses package development services; (2) To provide consultation by the appropriate experts in the design and application of relevant MRI methods, so that UPCI members can knowledgeably choose the most suitable technique for their research; (3) To provide access to the appropriate instrumentation and the technical, physical, and intellectual skills to carry out these techniques, so that UPCI members will be able to utilize efficient and cutting edge imaging methods in a convenient and economical fashion, including pulse sequence design and implementation, imaging protocol development, contrast agent syntheses, and data analyses package development. During the past year, UPCI has recruited two new faculty members with expertise in cancer imaging, and in parallel, in recent years both the University of Pittsburgh and Carnegie Mellon University, working closely together, have invested heavily in both small animal and human MRI fystems. The funds requested for this new Facility will provide partial support for individuals with the technical expertise, purchase of supplies, and provide imaging time, so that UPCI investigators can use in vivo molecular and cellular methods to gain new and noninvasive insights into the physiology, biology, and biochemistry of cancer, at a minimal cost, which are expected to lead to advances in the accurate diagnosis of primary and metastatic tumors, and the assessment of responses to therapy for cancer.