Dynamic MRM: Source of Specificity Errors and Solutions

动态 MRM:特异性错误的来源和解决方案

基本信息

  • 批准号:
    7112924
  • 负责人:
  • 金额:
    $ 40.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-09-24 至 2008-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Magnetic resonance mammography (MRM) is an imaging technique under development to overcome the limitations of X-ray mammography. One method uses permeability-surface area (PS) products derived from dynamic contrast enhancement (DCE) data to improve specificity. The specificity, 37 to 97%, obtained by this technique is controversial. DCE requires high temporal resolution to collect the kinetic information at the expense of spatial resolution. No one has reported if the averaging of the PS product, induced by partial volume effects, limits the effectiveness in using PS products to differentiate and grade tumors. We are testing the hypothesis that the spatial resolution used in human DCE MRM results in partial volume averaging that significantly reduces the prognostic information obtainable with PS products calculated from DCE-MRM data, and that reduced encoding methods that reconstruct images based on one reference image produce PS-products with partial volume averaging. We then demonstrate a technique to obtain images with both high temporal and spatial resolutions. We will accomplish these goals by studying the PS product of Gd(III)-DTPA in tumor region of interests in N-ethyI-N-nitrosourea induced rat mammary tumors as a function of both the in plane resolution and slice thickness. The PS values are calculated with a two compartment model at in plane resolutions that include those used clinically, 6.25 mm2, and at the "microscopic field" sizes used to analyze vascular density, 0.74 and 0.152 mm2, in vitro. PS values are correlated to tumor grade, vascular density, and vascular permeability factor obtained by in vitro histochemical methods. We apply a reduced encoding method to obtain DCE MRM data with both high temporal and spatial resolutions, and show that the PS product calculated from these images are accurate relative to those obtained with standard high spatial resolution techniques. The algorithm uses a generalized series method with both pre and post contrast enhanced reference images, TRIGR. The dynamic data obtained with low in plane resolution is reconstructed to high spatial resolution with TRIGR. This maintains the high temporal resolution. The protocol is then used with DCE MRM and a dendrimer based contrast agent to differentiate benign from malignant tumors and compared against histological methods.
描述(由申请人提供):

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Improved self-calibrated spiral parallel imaging using JSENSE.
  • DOI:
    10.1016/j.medengphy.2008.09.009
  • 发表时间:
    2009-06
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Sheng J;Wiener E;Liu B;Boada F;Ying L
  • 通讯作者:
    Ying L
ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain.
  • DOI:
    10.1158/1535-7163.mct-09-0953
  • 发表时间:
    2010-04
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Yiin JJ;Hu B;Schornack PA;Sengar RS;Liu KW;Feng H;Lieberman FS;Chiou SH;Sarkaria JN;Wiener EC;Ma HI;Cheng SY
  • 通讯作者:
    Cheng SY
High-resolution MR metabolic imaging.
高分辨率 MR 代谢成像。
A fluorinated dendrimer-based nanotechnology platform: new contrast agents for high field imaging.
基于氟化树枝状聚合物的纳米技术平台:用于高场成像的新型造影剂。
  • DOI:
    10.1097/rli.0b013e3181ee6e06
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    6.7
  • 作者:
    Huang,Zhihua;Sengar,RaghvendraS;Nigam,Archana;Abadjian,Marie-Caline;Potter,DouglasM;Grotjahn,DouglasB;Wiener,ErikC
  • 通讯作者:
    Wiener,ErikC
High-resolution diffusion MRI.
高分辨率扩散磁共振成像。
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ERIK C WIENER其他文献

ERIK C WIENER的其他文献

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{{ truncateString('ERIK C WIENER', 18)}}的其他基金

A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
树枝状聚合物纳米结构肾清除率设计标准的新维度
  • 批准号:
    7903737
  • 财政年份:
    2009
  • 资助金额:
    $ 40.45万
  • 项目类别:
A clinical animal MR imager designed for translational research: the 7T Clinscan
专为转化研究而设计的临床动物 MR 成像仪:7T Clinscan
  • 批准号:
    7498109
  • 财政年份:
    2009
  • 资助金额:
    $ 40.45万
  • 项目类别:
A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
树枝状聚合物纳米结构肾清除率设计标准的新维度
  • 批准号:
    7279608
  • 财政年份:
    2007
  • 资助金额:
    $ 40.45万
  • 项目类别:
A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
树枝状聚合物纳米结构肾清除率设计标准的新维度
  • 批准号:
    7898879
  • 财政年份:
    2007
  • 资助金额:
    $ 40.45万
  • 项目类别:
A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures
树枝状聚合物纳米结构肾清除率设计标准的新维度
  • 批准号:
    7671229
  • 财政年份:
    2007
  • 资助金额:
    $ 40.45万
  • 项目类别:
CORE--MRI
核磁共振成像
  • 批准号:
    6989548
  • 财政年份:
    2004
  • 资助金额:
    $ 40.45万
  • 项目类别:
Dynamic MRM: Source of Specificity Errors and Solutions
动态 MRM:特异性错误的来源和解决方案
  • 批准号:
    6949538
  • 财政年份:
    2003
  • 资助金额:
    $ 40.45万
  • 项目类别:
Dynamic MRM: Source of Specificity Errors and Solutions
动态 MRM:特异性错误的来源和解决方案
  • 批准号:
    6687242
  • 财政年份:
    2003
  • 资助金额:
    $ 40.45万
  • 项目类别:
Dynamic MRM: Source of Specificity Errors and Solutions
动态 MRM:特异性错误的来源和解决方案
  • 批准号:
    6803126
  • 财政年份:
    2003
  • 资助金额:
    $ 40.45万
  • 项目类别:
Folate Dendrimers as Tumor Specific Contrast Agents
叶酸树枝状聚合物作为肿瘤特异性造影剂
  • 批准号:
    6431238
  • 财政年份:
    2002
  • 资助金额:
    $ 40.45万
  • 项目类别:

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