A clinical animal MR imager designed for translational research: the 7T Clinscan

专为转化研究而设计的临床动物 MR 成像仪：7T Clinscan

• 批准号: 7498109
• 负责人: ERIK C WIENER
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498109
• 关键词: Adverse effects; Animal Experimentation; Animals; Applications Grants; Back; Biological; Biological Markers; Blood Vessels; Clinic; Clinical; Data; Dose; Early treatment; Exposure to; Funding; Housing; Human; Image; Magnetic Resonance; Magnetic Resonance Imaging; Maximum Tolerated Dose; Methods; Monitor; Nature; Operating System; Patients; Phase; Physiologic pulse; Physiological; Predisposition; Research; Resolution; Sorting - Cell Movement; System; Time; Translating; Translational Research; Translations; Treatment Cost; bench to bedside; cancer therapy; design; effective therapy; instrument; pre-clinical; public health relevance; response; treatment response; tumor

DESCRIPTION (provided by applicant): The purpose of this grant application is to provide funds towards the purchase of a small animal clinical magnetic resonance (MR) imager with additional research capabilities. The instrument is a 7T ClinscanTM which has the same field strength and operating system as the 7T and two 3T human MR imaging systems housed at the Magnetic Resonance Research Center (MMRC). The key components of this system are the 16 parallel receive channels and the operating system which makes the machine a key instrument in the ability to translate animal research into the clinic. The clinical nature of the instrument provides new MRI biomarkers for monitoring the response of tumors to new cancer treatments in a preclinical phase of research. The research capability enables new methods for acquiring MR images that were developed at the MRRC and which provide for collecting images with extremely high spatial and temporal resolution while allowing for the reduced contribution from susceptibility by using ultrashort (< 500 <s) echo times. This lets us collect physiological data relevant to tumors and their blood vessels at this higher field strength. This will allow us to determine maximum tolerate dose (MTD) and predict minimal biologic effective doses for these compounds. Tumor-imaging correlates of biologic effect (relaxivity DCE MRI and MRI&S) will be clarified, and applied in identifying correlates of early treatment response for use in humans. The one to one identity of the operating systems of the animal imager and the human imagers housed at the MRRC make shifting new imaging pulse sequences between the two machines highly efficient. This sort of translation between instruments cannot be accomplished on a basic Bruker Research instrument. In fact the Clinscan is the only MRI designed for translational research. PUBLIC HEALTH RELEVANCE: This instrument is a key translational instrument and enables bench to bedside and back again. By being able to identify MTD, the highest dose that induces a biological response, and identify imaging correlates of early tumor response to treatment we can identify those non responding patients, move them onto more effective therapies earlier, reduce needless exposure to debilitating side effects, and reduce the overall cost of treatment.

描述（由申请人提供）：本拨款申请的目的是为购买具有额外研究能力的小动物临床磁共振（MR）成像仪提供资金。该仪器是一台7T ClinscanTM，具有与7T相同的场强和操作系统，以及位于磁共振研究中心（MMRC）的两台3T人体磁共振成像系统。该系统的关键部件是16个并行接收通道和操作系统，这使得该机器成为将动物研究转化为临床的关键仪器。该仪器的临床性质为在临床前研究阶段监测肿瘤对新的癌症治疗的反应提供了新的MRI生物标志物。研究能力使MRRC开发的获取MR图像的新方法成为可能，这些方法提供了极高的空间和时间分辨率的图像收集，同时允许使用超短（< 500 <s）回波时间来减少敏感性的贡献。这使我们能够在更高的磁场强度下收集与肿瘤及其血管相关的生理数据。这将使我们能够确定这些化合物的最大耐受剂量（MTD）并预测这些化合物的最小生物有效剂量。生物效应的肿瘤成像相关因素（弛豫DCE MRI和MRI& s）将被澄清，并应用于确定人类早期治疗反应的相关因素。MRRC的动物成像仪和人类成像仪的操作系统是一对一的，这使得在两台机器之间转换新的成像脉冲序列非常高效。这种仪器之间的转换不能在基本的布鲁克研究仪器上完成。事实上，Clinscan是唯一为转译研究设计的MRI。