A clinical animal MR imager designed for translational research: the 7T Clinscan

专为转化研究而设计的临床动物 MR 成像仪：7T Clinscan

• 批准号: 7498109
• 负责人: ERIK C WIENER
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498109
• 关键词: Adverse effects; Animal Experimentation; Animals; Applications Grants; Back; Biological; Biological Markers; Blood Vessels; Clinic; Clinical; Data; Dose; Early treatment; Exposure to; Funding; Housing; Human; Image; Magnetic Resonance; Magnetic Resonance Imaging; Maximum Tolerated Dose; Methods; Monitor; Nature; Operating System; Patients; Phase; Physiologic pulse; Physiological; Predisposition; Research; Resolution; Sorting - Cell Movement; System; Time; Translating; Translational Research; Translations; Treatment Cost; bench to bedside; cancer therapy; design; effective therapy; instrument; pre-clinical; public health relevance; response; treatment response; tumor

DESCRIPTION (provided by applicant): The purpose of this grant application is to provide funds towards the purchase of a small animal clinical magnetic resonance (MR) imager with additional research capabilities. The instrument is a 7T ClinscanTM which has the same field strength and operating system as the 7T and two 3T human MR imaging systems housed at the Magnetic Resonance Research Center (MMRC). The key components of this system are the 16 parallel receive channels and the operating system which makes the machine a key instrument in the ability to translate animal research into the clinic. The clinical nature of the instrument provides new MRI biomarkers for monitoring the response of tumors to new cancer treatments in a preclinical phase of research. The research capability enables new methods for acquiring MR images that were developed at the MRRC and which provide for collecting images with extremely high spatial and temporal resolution while allowing for the reduced contribution from susceptibility by using ultrashort (< 500 <s) echo times. This lets us collect physiological data relevant to tumors and their blood vessels at this higher field strength. This will allow us to determine maximum tolerate dose (MTD) and predict minimal biologic effective doses for these compounds. Tumor-imaging correlates of biologic effect (relaxivity DCE MRI and MRI&S) will be clarified, and applied in identifying correlates of early treatment response for use in humans. The one to one identity of the operating systems of the animal imager and the human imagers housed at the MRRC make shifting new imaging pulse sequences between the two machines highly efficient. This sort of translation between instruments cannot be accomplished on a basic Bruker Research instrument. In fact the Clinscan is the only MRI designed for translational research. PUBLIC HEALTH RELEVANCE: This instrument is a key translational instrument and enables bench to bedside and back again. By being able to identify MTD, the highest dose that induces a biological response, and identify imaging correlates of early tumor response to treatment we can identify those non responding patients, move them onto more effective therapies earlier, reduce needless exposure to debilitating side effects, and reduce the overall cost of treatment.

描述（由申请人提供）：本赠款申请的目的是为购买具有其他研究功能的小型动物临床磁共振（MR）成像仪提供资金。该仪器是一种7T夹层，其具有与磁共振研究中心（MMRC）所容纳的7T和两个3T人类MR成像系统相同的场强度和操作系统。该系统的关键组成部分是16个平行接收通道和操作系统，这使机器成为将动物研究转化为诊所的关键工具。该仪器的临床性质提供了新的MRI生物标志物，用于在临床前研究阶段监测肿瘤对新癌症治疗的反应。该研究能力可实现新的方法来获取在MRRC上开发的MR图像，并提供了以极高的空间和时间分辨率收集图像，同时允许使用Ultrashort（<500 <s）回声时间降低易感性的贡献。这使我们能够收集与肿瘤及其血管相关的生理数据。这将使我们能够确定最大耐受剂量（MTD），并预测这些化合物的最小生物学有效剂量。将阐明生物学效应（松弛性DCE MRI和MRI＆S）的肿瘤成像相关性，并应用于识别早期治疗反应的相关性，以便于人类使用。动物成像仪和人类成像仪的操作系统的一对一身份在MRRC上的一对一身份使两台机器之间的新成像脉冲序列在两台机器之间转移。工具之间的这种翻译无法在基本的布鲁克研究工具上完成。实际上，Clinscan是唯一设计用于转化研究的MRI。 公共卫生相关性：该工具是一种关键的翻译工具，使长凳可以床头再返回。通过能够鉴定MTD，这是诱导生物学反应并确定早期肿瘤反应对治疗的成像相关的最高剂量，我们可以识别那些不反应的患者，将其移至更有效的疗法中，减少不必要的衰减副作用，并降低总体治疗成本。