SCIENTIFIC CORE

科学核心监督CEDAR的调查工作，并负责该中心的战略计划的发展。这一核心统一了中心的研究活动，使中心的垂直一体化，并制定了长期的中心范围内的共同科学使命。研究方案的实施通过与研究模块和临床核心的密切合作来管理。与行政核心一起，研究活动在时间表、预算和人事管理方面持续不断。 中心的所有研究模块和核心都为实现中心范围的目标提供信息和支持，由计算和信息系统核心管理的公共数据库提供便利。对全中心具体目标的分析与方法和统计核心相协调。科学核心通过每两周一次的会议，监测实现中心范围内具体目标的科学进展，这些目标是：（1）得出儿童晚期和青春期SUD易感性的连续指数;（2）测试 儿童期行为和情感失调的程度是由生物成熟和环境压力之间的相互作用引起的，预测物质参与和SUD结果的理论;（3）探索SUD变体的可能性。

The Scientific Core oversees CEDAR's investigative work and is responsible for the Center's strategic program development. This Core unifies the Center's research activities, enabling the Center's vertical integration, and formulates a long-term center-wide common scientific mission. Implementation of research protocols is managed via close collaboration with the Research Modules and Clinical Core. In conjunction with the Administrative Core, research activities are maintained on an ongoing basis with respect to timelines, budget, and personnel management. All the Center's research modules and cores provide information and support for achieving center-wide goals, facilitated by the common database managed by the Computing and Information Systems Core. The analyses of the center-wide specific aims are coordinated in conjunction with the Methodology and Statistics Core. The Scientific Core, through bi-weekly meetings, monitors scientific progress toward achieving the center-wide specific aims, which are: (1) Derive a continuous index of SUD liability in late childhood and adolescence; (2) Test the theory that magnitude of behavioral and affective dysregulation in childhood resulting from the interaction between biological maturation and environmental stress, predicts substance involvement and SUD outcomes; and (3) Explore the possibility of deriving variants of SUD.