Dissecting the link between Clostridioides difficile, the intestinal microbiota and host factors to determine patient outcome.

艰难梭菌是世界范围内院内抗生素相关性腹泻的主要原因，但对肠道定植和疾病复发知之甚少。用抗生素治疗潜在疾病会改变肠道菌群，导致对艰难梭菌定植的易感性。目前的数据显示，20-30%的艰难梭菌感染（CDI）患者在治疗后2个月内复发，且多次复发的可能性越来越大，表明存在艰难梭菌的潜在储存库，重新播种易感患者的肠道。我们认为存在与艰难梭菌疾病相关的独特群落和蛋白质组学特征。

Clostridioides difficile is the leading cause of nosocomial antibiotic-associated diarrhoea worldwide, yet little is known about colonisation of the intestinal tract and disease relapse. Treatment with antibiotics for an underlying condition alters the intestinal microbiota, which results in susceptibility to colonisation with C. difficile. Current data indicates that 20-30% of patients suffering from C. difficile infection (CDI) relapse within two months post-treatment with increasing probability of relapsing multiple times, indicating the presence of a potential reservoir of C. difficile re-seeding the intestinal tract of susceptible patients. We suggest there are there are distinct community and proteomic signatures linked to C. difficile disease.