Addressing antimicrobial resistance with peptides: novel sactipeptides from genome mining

抗生素耐药性是对全球公共卫生的巨大威胁，迫切需要新的化合物来解决这一不断升级的危机。细菌天然产物是这类化合物的巨大储存库。乳酸肽是一类具有生物活性和选择性的肽类细菌天然产物。利用基因组挖掘技术已经预测了已知细菌物种中的几种乳糖肽，[1]尽管迄今为止只有六种被分离和表征。因此，本项目的目的是从细菌中鉴定新的sactepeptides，鉴定其结构和活性，并研究使用sacteptide生物合成机制生产类似物。

Antimicrobial resistance is a huge threat to global public health and new compounds areurgently needed to address this escalating crisis. Bacterial natural products are a vastreservoir of such compounds. One class of peptidic bacterial natural products with promisingactivities and selectivities are the sactipeptides. Several sactipeptides have been predicted inknown bacterial species using genome mining,[1] though only six have been isolated andcharacterised to date. The aim of this project is therefore to identify novel sactipeptides frombacteria, characterise their structure and activity, and investigate the production ofanalogues using the sactipeptide biosynthetic machinery.