Chronic Kidney Disease with Benign Prostatic Hyperplasia

描述（由申请人提供）：良性前列腺增生（BPH）和慢性肾脏疾病（CKD）都是老年男性常见的疾病。先前的研究着眼于这两种疾病之间的关系，是在干预时对3PH患者进行的病例系列研究，经常与急性尿潴留混淆。BPH及其尿路感染（UTI）并发症可能是CKD发展的未被重视的危险因素。这项研究将使用一项基于社区的前瞻性纵向队列研究的数据，该研究对2311名男性进行了为期13年的BPH并发症随访。使用线性混合效应回归模型和逻辑回归模型，将评估基线BPH替代测量和/或尿路感染史与CKD发展之间的关系。基线BPH替代测量包括症状评分、峰值尿流率、剩余尿量和前列腺大小。CKD的发展将通过两年期血清肌酐的纵向变化来评估。已知的CKD危险因素，如糖尿病和高血压，将从医疗记录中提取出来，并作为潜在的混杂因素进行调整。根据初步数据，BPH替代测量与CKD之间存在显著关联。这项研究将阐明早期评估和干预BPH是否有必要预防CKD。

DESCRIPTION (provided by applicant): Benign Prostatic Hyperplasia (BPH) and Chronic Kidney Disease (CKD) are both common medical conditions in aging men. Prior studies looking at the association between these two diseases have been case series of 3PH patients at the time of intervention, often confounded by acute urinary retention. BPH and its urinary tract infection (UTI) complication may be under-appreciated risk factors for the development of CKD. This study will use data from a community-based prospective longitudinal cohort study of 2311 men followed for complications of BPH over 13 years. Using both a linear mixed effects regression model and a logistic regression model, the relationship between a baseline BPH surrogate measure and/or UTI history with the development of CKD will be assessed. Baseline BPH surrogate measures are a symptom score, peak urinary flow rate, residual urine volume, and prostate size. Development of CKD will be assessed through biennial longitudinal changes in serum creatinine. Known risk factors for CKD such as diabetes mellitus and hypertension will be abstracted from the medical record and adjusted for as potential confounders. Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD.