Molecular Regulation of CD8 T Cell Memory by BCL-6

描述（由申请人提供）：暴露于抗原后，宿主淋巴细胞经历分化过程，产生抗原特异性记忆淋巴细胞。记忆T细胞提供了抗原特异性淋巴细胞库，能够在抗原再次暴露后快速反应。虽然人们开始在细胞水平上理解T细胞记忆，但对记忆中涉及的转录调控却知之甚少。最近的遗传数据已经确定了bcl-6，一种序列特异性转录抑制因子，作为CD8 T细胞记忆的调节因子。本提案将通过定义bcl-6在记忆性CD8 T细胞发育和存活中的动力学和功能，重点关注bcl-6在CD8记忆性T细胞生成中的作用。这些研究将深入了解CD8 T细胞记忆的分子调控。此外，他们可能会确定特定的方法来增强CD8 T细胞的记忆，以帮助清除感染，或防止自身反应性CD8记忆T细胞的不适当发展。

DESCRIPTION (provided by applicant): Following exposure to antigen, host lymphocytes go through a process of differentiation resulting in the generation of antigen-specific memory lymphocytes. Memory T cells provide a pool of antigen-specific lymphocytes capable of rapid response following antigen re-exposure. While T cell memory is beginning to be understood at the cellular level, the transcriptional regulation involved in memory is poorly understood. Recent genetic data have identified bcl-6, a sequence-specific transcriptional repressor, as a regulator of CD8 T cell memory. This proposal will focus on the role of bcl-6 in the generation of CD8 memory T cells, by defining the kinetics and function of bcl-6 in memory CD8 T cell development and survival. These studies will provide insight into the molecular regulation of CD8 T cell memory. Furthermore, they may identify specific methods to accentuate CD8 T cell memory to aid in clearance of infection, or to prevent inappropriate development of autoreactive CD8 memory T cells.