Ped Endocrine Career Development in Diabetes Research

描述(由申请人提供)： 这一职业发展计划的目标是培养新一代儿科内分泌学家，他们将具备在新的21世纪开展创新的、科学严谨的、以患者为导向的、以实验室为基础的儿童糖尿病研究的能力。该计划的需求之一是糖尿病研究中严重缺乏学术儿科内分泌学家，这一点受到了美国糖尿病协会、青少年糖尿病研究基金会和儿科学术学会等组织的重视。此外，该计划认识到，人类基因组计划等最新的科学进步以及在胰岛移植和生产生物机械和生物工程胰岛方面的成功，为促进儿童糖尿病研究提供了重要的新机会。该计划将支持学者在初级教员层面进行长达3年的研究职业发展。该项目的教职员工包括来自儿童医院和宾夕法尼亚大学医学院的19名科学导师，他们拥有出色的资历，并有积极的研究项目和培训记录。这些导师将通过与儿童糖尿病相关的基础实验室研究和/或以患者为导向的研究来监督学者的职业发展。职业发展机会将包括三个主要的基础研究领域：1)信号转导：激素作用机制；2)胰腺β细胞功能和发育的调节；以及3)糖尿病和内分泌疾病的遗传方法。面向患者的研究机会将包括：1)胰岛免疫学、移植和调节；2)肥胖和胰岛素抵抗；3)糖尿病并发症；4)糖尿病流行病学和生物统计学。该计划包括所有研究方面的正规培训课程，包括生物统计学、生物伦理学、分子生物学等。该计划得到了一系列极好的机构资源的大力支持，包括CHOP GCRC和UPenn DERC。本计划每年申请2个被任命的职位。

DESCRIPTION (provided by applicant): The goal of this Career Development Program Is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative, scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children for this new 21st Century. One of the needs for this Program is the critical shortage of academic pediatric endocrinologists in diabetes research which has been emphasized by the organizations such as the American Diabetes Association, the Juvenile Diabetes Research Foundation, and the Pediatric Academic Societies. In addition, the Program recognizes the important new opportunities for advancing diabetes research in children provided by such recent scientific advances as the Human Genome Project and the successes in islet transplantation and production of biomechanical and bioengineered islets. The Program will support Scholars for up to 3 years of research career development at the junior faculty level. The Program faculty includes 19 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials and active research programs and training records. These mentors will supervise Scholars' career development through basic laboratory research and/or patient-oriented research related to diabetes in children. Career development opportunities will include 3 major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action; 2) Regulation of Pancreatic beta-Cell Function and Development; and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation; 2) Obesity and Insulin Resistance, 3) Diabetes Complications; and 4) Diabetes Epidemiology and Biostatistics. The Program includes a curriculum of formal training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year.