CORE--IMAGING

许多研究人员在他们的研究中融入了组织成像技术。这些成像方法是 然而，以不同程度的技术成熟度、解剖细节、组织质量和技术专长进行。在几乎所有的情况下，在有经验的实验室人员的协助下，都有可能进行技术改进。为了提供这一关键的技术支持，并改进数字成像在正在进行的、待定的和新的研究中的应用，我们建议建立一个成像核心。俄勒冈州听力研究中心成像核心(核心2)将支持由NIDCD和其他机构资助的五名主要研究人员，他们在外围和中央听觉-前庭感觉通路成像方面具有强大的重点和大量的成就记录。总体目标是将光、共焦和电子显微镜成像方面的专门知识集中在OHRC内，以加强目前资助的研究项目，允许开发新项目，并鼓励参与调查人员之间的合作。显微镜和成像核心(核心2)将：1：提供行政和技术监督，以改善设施功能。2：提供人员协助调查人员进行当前和新的研究。3：以更具成本效益和效益的方式提供维护良好的设备。4：为调查人员及其工作人员提供培训，以提高现有技术能力的应用。《影像核心》将由丹尼斯·特鲁恩和彼得·斯泰格共同执导。通过提供现有赠款无法提供的服务，显微镜和成像核心将加强核心设施用户目前、计划和未来开展的新研究项目，并促进富有成效的合作。

Numerous investigators incorporate tissue imaging in their studies. These imaging methods are conducted, however, with varying degrees of technical sophistication, anatomical detail, tissue quality, and technical expertise. In nearly all cases, there is potential for technical refinement when assisted by experienced laboratory personnel. To provide this critical technical support and improved application of digital imaging in ongoing, pending, and new studies, we propose to establish a Imaging Core. The Oregon Hearing Research Center Imaging Core (Core 2) will support five principal investigators, funded by the NIDCD and other institutes, with strong focus and a substantial record of accomplishments in imaging the periphery and central audito-vestibular sensory pathway. The overall goal is to centralize expertise in light, confocal and electron-microscopic imaging within the OHRC to enhance presently-funded research projects, permit development of new projects, and stimulate collaborations between participating investigators. The Microscopy and Imaging Core (Core 2) will: 1: Provide administrative and technical oversight to improve facility function. 2: Provide personnel who will assist investigators with current and new studies. 3: Provide access to well-maintained equipment in a more cost-efficient and effective manner. 4: Provide training to investigators and their staffs to improve application of existing technical capabilities. The Imaging Core will be co-directed by Dennis Trune and Peter Steyger. By providing services not available through existing grants, the Microscopy and Imaging Core will enhance current, planned and future new research projects carried out by core-facility users and stimulate productive collaborations.