A nanostructured coating platform technology for protection and functionalisation of magnesium-based implants

可降解金属在提高包括心血管和骨科在内的许多临床领域的医疗植入物的性能方面具有重要的潜力。近年来，镁作为可降解医用植入物的生物材料受到越来越多的关注。实现这一潜力的主要限制是在生理系统的高氯化物环境中，镁在生理pH值下的不受控制的、快速的腐蚀。为了控制降解，人们使用了合金化Mg和涂层/表面处理。在这些方面取得的成功充其量是有限的。本提案旨在展示PVD涂层技术的潜力，以提供镁基植入式医疗器械的定制降解。该技术包括一种新颖的创新多相纳米结构涂层，以控制镁植入医疗设备的耐久性。多层涂层将包含一种新型的非晶填充层，该非晶填充层填充可降解层中的缺陷，以防止裂缝腐蚀加速控制层。这是一种用于电介质材料的方法，该研究的一部分将是建立生物相容性版本。这些涂层的发展将以高影响力的基础科学为基础，以了解纳米结构涂层的组成、结构和降解机制之间的关系。

Degradable metals have significant potential for enhancing performance of medical implants in a number of clinical fields including cardiovascular and orthopaedics. Magnesium has attracted increasing attention as a biomaterial for degradable medical implants in recent years. The principal limitation to realising this potential is the uncontrolled, rapid, corrosion of magnesium at physiological pH in the high chloride environment of the physiological system. Attempts to control degradation have used alloying Mg and coatings/surface treatments. Success with these have been modest at best. This proposal aims to demonstrate the potential for PVD coating technology to provide tailored degradation of magnesium-based implantable medical device. The technology comprises a novel innovative multiphase nanostructured coating to control the durability of magnesium implantable medical devices. The multilayer coatings will contain a novel amorphous filling layer that fills defects in the degradable layer to prevent crevice corrosion accelerating the control layer. This is an approach that is used for dielectric materials and part of this research will be to establish a biocompatible version. The development of these coatings will be underpinned by high impact fundamental science to understand the relationship between composition, structure and mechanism of degradation of the nanostructured coatings.