Cancer Center Support Grant

描述（由申请人提供）：华盛顿大学医学院和巴恩斯犹太医院的Alvin J. Siteman癌症中心（SCC）于2001年被NCI指定为临床癌症中心。 SCC由八个多学科研究计划组成：癌症遗传学，癌症和发育生物学，肿瘤免疫学，造血发育和造血，细胞增殖，预防和控制，转化和临床研究以及肿瘤成像。 该计划的研究工作得到了14个共享资源的支持，其中两个正在开发中：胚胎干细胞核心，组织采购核心，分子核心实验室，多重基因分析核心，小动物癌症成像核心，高速细胞分选核心，蛋白质组学核心，遗传性癌症核心，药理学核心，生物信息学核心，生物统计学核心，临床试验核心，健康行为和外展核心（发展中）和良好生产规范设施（发展中）。 自2000年10月提交第一份癌症中心支助补助金申请以来，SCC取得了显著进展。成员数目保持相对稳定，自2000年以来增加了18个成员。 跨学科的协调与合作通过一系列机制得到了显著加强，包括制定了一个科学框架，展示了SCC四个主要领域-基础科学，转化和临床研究，预防和控制以及肿瘤成像之间的相互促进作用。 研究围绕四个科学主题组织，这些主题整合了这些领域：癌症的遗传基础;癌症生物学和发展;创新诊断和治疗;和化学预防。 主要的进展指标包括：计划间出版物从2000年的23%增加到2003年的28%;综合性、多学科、计划赠款从2000年的8项增加到2003年的17项。 这一进展直接归功于一个富有成效的成员，这是密切关注癌症研究，研究行政人员谁提供支持和指导，在多项目赠款的发展，并从事高级领导人谁致力于促进合作，转化研究。

DESCRIPTION (provided by applicant): The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001. The SCC is composed of eight multidisciplinary research programs: Cancer Genetics, Cancer and Developmental Biology, Tumor Immunology, Hematopoietic Development and Malignancy, Cellular Proliferation, Prevention and Control, Translational and Clinical Research, and Oncologic Imaging. Research efforts in the programs are supported by 14 shared resources, two of which are under development: Embryonic Stem Cell Core, Tissue Procurement Core, Molecular Core Laboratory, Multiplexed Gene Analysis Core, Small Animal Cancer Imaging Core, High Speed Cell Sorter Core, Proteomics Core, Hereditary Cancer Core, Pharmacology Core, Bioinformatics Core, Biostatistics Core, Clinical Trials Core, Health Behavior and Outreach Core (developing) and Good Manufacturing Practice Facility (developing). Since submission of the first Cancer Center Support Grant application in October 2000, the SCC has made outstanding progress. Membership has remained relatively stable, with an increase of 18 members since 2000. Interdisciplinary coordination and collaboration has been significantly enhanced through a number of mechanisms, including development of a scientific framework that demonstrates cross-fertilization among the four major areas of the SCC - Basic Science, Translational and Clinical Investigation, Prevention and Control, and Oncologic Imaging. Research is organized around four scientific themes that integrate these areas: Genetic Basis of Cancer; Cancer Biology and Development; Innovative Diagnostics and Therapeutics; and Chemoprevention. Key indicators of progress include an increase in inter-programmatic publications from 23% in 2000 to 28% in 2003; and an increase in the number of integrated, multidisciplinary, programmatic grants from 8 in 2000 to 17 in 2003. This progress is directly attributable to a productive membership that is tightly focused on cancer research, research administrative staff who provide support and guidance in the development of multi-project grants, and engaged Senior Leaders who are committed to fostering collaborative, translational research.