Basal Ganglia and 5-HT in Ritualistic Social Displays

描述(由申请者提供)：社会/领土的仪式性展示 地位是物种内相互作用的重要调节者，降低了成本 无论是对个人还是对整个团队来说，都是竞争的结果。这种仪式性的行为 在广泛的陆地脊椎动物(海洋动物)中都有类似的形式。当 大脑机制调节它们在人类中的功能障碍，结果可能是肯定的 强迫症，强迫症强迫症的特征 强迫症(OCD)、多发性抽动症(GTS)、社交恐惧症和一些情绪 精神错乱。 首席研究员和其他人的功能神经成像研究 提示皮质/边缘-基底节-丘脑(=BG)系统参与 强迫症和相关抑郁症的症状。与Anolis蜥蜴合作建议 羊膜-类属背外侧(DL)与腹内侧(Vm)BG系统 分别调解一般的显性社交表现和顺从的社交表现。这 研究还表明，血清素(5-羟色胺)在确定 主导或顺从的行为是在特定的语境中表达的，以及 强烈提示Anolis 5-HTIB受体决定5-羟色胺的分化 与支配行为和顺从行为有关的通量。我们的人类和蜥蜴的发现 共同导致了这样一个论点，即BG系统组织为 交叉抑制的DL与VM子系统相互作用，使行为偏向于 一般的支配与顺从的行为惯例。当DL/VM BQ子系统 人类的相互作用功能障碍，结果可能是固定的， 上下文-不恰当的行为，如强迫症/抑郁(顺从/顺从/ 失败)，从而解释了人类PET的发现。相反，攻击性国家 具有支配行为的刻板印象(例如，躁狂、QTS)，可能会有 互惠的BG系统功能障碍。 因此，更全面地了解BQ系统如何相互作用并受到 5-羟色胺在社交/地域展示行为中的中介作用 适当的、易于操作的模型系统是有价值的。通过使用 药理学挑战、体内功能放射自显影和原位 杂交，我们建议阐明BG的最近的机制，通过 雄性Anolis蜥蜴被矢量化以显示优势与从属 社会/地域行为惯例，以及这些行为和他们的 调节大脑的功能在这些状态的两极之间切换 社会/冲突经历的结果。

DESCRIPTION (provided by applicant): Ritualistic displays of social/territorial status are important regulators of intra-species interactions, reducing costs of competition for both individuals, and the group. Such ritualistic behaviors have similar forms across a wide range of land vertebrates (anmiotes). When the brain mechanisms mediating them dysfunction in man, the result may be certain psychopathologies, such as those characteristic of obsessive compulsive disorder (OCD), Tourette's disorder (GTS), social phobia, and some mood disorders. Functional neuroimaging studies by the Principal Investigator and others suggest that cortico/limbic-basal ganglionic-thalamic (=BG) systems mediate symptoms seen in OCD and related depressions. Work with Anolis lizards suggest that amniote- generic dorsolateral (DL) vs. ventro-medial (VM) BG systems mediate generic dominant vs. submissive social displays, respectively. This work has also demonstrated an acute role for serotomn (5-HT) in determining whether dominant or submissive behaviors are expressed in a given context, and strongly suggest that Anolis 5-HTIB receptors determines the differential 5-HT flux related to dominant vs. submissive behavior. Our human and lizard findings together have lead to a thesis that BG systems are organized as cross-inhibitory DL vs. VM subsystems that interact to bias behavior toward generic dominant vs. submissive behavioral routines. When DL/VM BQ subsystem interactions dysfunction in humans, the result may be fixed, context-inappropriate behaviors, as seen in OCD/depressions (submissive/ defeat), thus explaining the human PET findings. Conversely, aggressive states with stereotypic displays of dominance behavior (e.g., mania ,QTS), might have reciprocal BG system dysfunctions. Thus, a fuller understanding of how BQ systems interact and are regulated by 5-HT functions to mediate social/territorial display behaviors in an appropriate, easily manipulated model system is of value. By using pharmacological challenges, in vivo functional autoradiography, and in situ hybridization, we propose to elucidate the proximate BG mechanisms by which male Anolis lizards are vectored to display dominant vs. subordinate social/territorial behavioral routines, and how these behaviors and their mediating brain functions are switched between these poles of status as a result of social/conflict experience.