Brain Lateralization in Adolescent Psychosis

描述(由申请人提供)：我们正在申请5年的支持 青少年精神病患者的脑偏侧化研究。精神障碍 在科学上或临床上还没有很好地理解青少年，而且 青少年精神病的病因、预后和最佳治疗方法仍然存在 不确定。青少年在以生物为导向的社会中的代表性不足 神经精神病学研究，特别是在最近发展的背景下 功能和结构脑成像指标在我们的 提高了对成年人精神病的理解。我们提议进行一项正式的研究 青春期发作的精神病患者实施某些新的非侵入性 已显示出重大承诺的指标将提高我们对 患有精神病的成年人的疾病过程，包括 脑磁图(MEG)功能测量和磁共振 成像(MRI)结构措施。在患有精神障碍的成年人中，我们有 已发表的脑磁图和磁源成像(MSI)测量异常 大脑的结构和功能偏侧化。这些发现似乎表明 随着几个主要疾病的精神病的存在或不存在而不同 神经精神障碍，有一些建议，特别是 异常偏侧的模式可能会将这些疾病与一种 又一个。这种异常，如果出现在早发青少年中， 未分化的精神病，可能有助于1)更早和更准确 诊断，2)改进了发病时的治疗计划，3)更准确 疾病轨迹和预后的估计，以及未来的家庭研究 大脑偏侧化的遗传学。

DESCRIPTION (Provided by Applicant): We are requesting 5 years of support for a study of brain lateralization in adolescent psychosis. The psychotic disorders in adolescents are not well understood scientifically or clinically, and the etiology, prognosis, and optimal treatments for psychosis in adolescents remain uncertain. Adolescents are underrepresented in biologically oriented neuropsychiatric research, especially within the context of recently developed functional and structural brain imaging metrics that have shown promise in our improved understanding of psychoses in adults. We are proposing a formal study of adolescent onset psychoses implementing certain of the new non-invasive metrics that have shown significant promise to improve our understanding of disease process in adults with psychotic disorders, including magnetoencephalography (MEG) functional measures, and magnetic resonance imaging (MRI) structural measures. in adults with psychotic disorders, we have published MEG and magnetic source imaging (MSI) measures of anomalous structural and functional lateralization of the brain. These findings appear to vary with the presence or absence of psychosis across several major neuropsychiatric disorders, and there is some suggestion that the specific patterns of anomalous lateralization may differentiate these disorders from one another. Such abnormalities, if present in adolescents with early onset, undifferentiated psychosis, may contribute to 1 ) earlier and more accurate diagnosis, 2) improved treatment planning at onset of illness, 3) more accurate estimate of illness trajectory and prognosis, as well as future family studies of the genetics of brain lateralization.