Type 1 Resistant Starch: A journey through the gut

英国大多数成年人超重或肥胖，迫切需要更健康的加工食品。一种解决方案是将饮食中的“可用淀粉”替换为“抗性淀粉”，这种“抗性淀粉”在上肠道不易被葡萄糖消化，因此进入结肠。来自豆类的可食用植物组织是1型抗性淀粉(RS1)的天然来源，但RS1的饮食摄入量从未被系统地记录下来。此外，这些结构对食物加工和消化的弹性还没有被很好地理解--这些结构是如何逃脱上部肠道的消化的？进入结肠的消化食物的性质是什么？在这个项目中，分离的植物细胞将被用来研究RS1的消化命运及其对驻留在人类肠道中的微生物群的影响。

Most adults in the UK are overweight or obese, and healthier processed foods are urgently needed. One solution is to replace 'available starch' in the diet with 'resistant starch' that is not readily digested to glucose in the upper-gut, and therefore enters the colon. Edible plant-tissues from pulses are a natural source of Type 1 Resistant starch (RS1), but the dietary intake of RS1 has never been systematically documented. Furthermore, the resilience of these structures to food processing and digestion are not well understood - How do these structures escape digestion in the upper gut? What is the nature of the digested food material that enters the colon? Are the resident microbiota capable of disassembling these resistant starch structures?In this project isolated plant cells will be used to study the digestive fate of RS1 and its impact on the microbiome that resides in the human gut.