Gated Optical Detectors/Dose Guided Radiotherapy

与海军研究实验室合作开发的光学辐射探测器已经形成了一种探测系统，该系统使用加速器枪触发脉冲作为数据采集的电子门，从而消除了切伦科夫辐射引起的与场和剂量率相关的污染物。得到的探测器体积小，灵敏度高，具有线性响应和宽动态范围。已经进行了幻影研究，目前正在进行有限的临床部署。初始阶段是研究少量离散纤维在剂量验证中的临床应用。下一步是将纤维阵列发展为矩形或螺旋网格，并研究放射治疗期间产生的剂量图以及器官或光束位置的微小变化的影响。第三个阶段是了解相对于患者解剖位置的信号变化的含义，如果检测到的信号与参考值相差预定的容差，则中断治疗。第四个也是最后一个阶段是将网格信号的变化与辐射场的校正变化动态联系起来，用于在线、动态的放射治疗剂量控制。

The development of optical radiation detectors in conjunction with the Naval Research Laboratories has resulted in a detection system that employes the accelerator gun trigger pulses as an electronic gate for data acquisition; thereby eliminating the field and dose rate dependent contaminant due to Cerenkov radiation. The resulting detector is small and very sensitive, with a linear response and a wide dynamic range. Phantom studies have been performed and limited clinical deployment is underway. The initial phase is to stude the clinical utility of a small number of discrete fibers in dose verification. The next step is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. The third phase is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. The fourth and final phase is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments.