Human Decidual Lymphocytes and their Placental Ligands

超出所提供的空间。本研究的具体目的是研究人类蜕膜淋巴细胞的受体、配体和功能，以期了解它们在植入和妊娠中的可能作用。我们尤其希望。”． 研究可能参与免疫反应下调的人蜕膜自然杀伤细胞（NK）过度表达的新蛋白的生物化学和可能的功能，继续分析这些细胞的转录谱，并研究它们的细胞毒性和分泌细胞因子的能力。通过研究不变性NKT （iNKT）细胞与几种细胞类型上表达的CDld的相互作用，检测其V_库与细胞因子分泌的关系，验证其在母胎界面调节免疫反应的假设，以及检测其完整的转录谱，来评估iNKT细胞在蜕膜中的作用。检测胎盘中NK和iNKT细胞和GM-CSF受体的I类MHC蛋白配体的表达，并检测胎盘外细胞滋养细胞与NK和iNKT细胞以及GM-CSF的相互作用。= ERFORMANCE网站(S)(组织、城市、国家)哈佛大学,剑桥,关键人员 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED. The specific aims of this research are to examine the receptors, ligands, and functions of human decidual lymphocytes with a view to understanding their possible roles in implantation and pregnancy. In particular, we wish." . To examine the biochemistry and possible functions of novel proteins overexpressed by human decidual natural killer (NK) cells that may be involved in down-modulation of the immune response, to continue analysis of the transcriptional profiles of these cells and to study their cytoxicity and ability to secrete cytokines. . To assess the role of invariant NKT (iNKT) cells in the decidua by studying their interaction with CDld expressed on several cell types, by examining the relation of their V_ repertoire to cytokine secretion, by testing the hypothesis that they function to regulate the immune response at the maternal-fetal interface and by examining their complete transcriptional profiles. . To examine the expression in the placenta of putative Class I MHC protein ligands for decidual NK and iNKT cells and of the GM-CSF receptor and to examine the interaction of placental extravillous cytotrophoblasts with NK and iNKT cells and with GM-CSF. =ERFORMANCE SITE(S) (organization, city, state) Harvard University, Cambridge, MA KEY PERSONNEL ========================================Section End===========================================