A Green Synthesis of Docosanoic Acid using Thraustochytrids and Biocompatible Chemistry

这个高度跨学科的项目将结合海洋藻类的小分子生产与生物相容性的非酶反应，以获得对制药和化妆品行业重要的小分子。这种独特的方法将首次在这种生物体中应用化学催化，重新定向其代谢，并使人们能够获得仅使用合成生物学无法获得的一类化合物。因此，该项目提供了一个独特的培训环境，以获得广泛的化学和生物实验室技术的经验：包括合成生物学，化学合成，微生物学（特别是专注于优化各种藻类的生长）以及使用HPLC， GC-MS和NMR等分析技术分析这些实验产生的微生物代谢物

This highly multidisciplinary project will combine small molecule production in marine algae with a biocompatible non-enzymatic reaction to access small molecules of importance to the pharmaceutical and cosmetics industry. This unique approach will apply chemical catalysis in this living organism for the first time, redirect its metabolism and enable access to a class of compounds that cannot be achieved using synthetic biology alone.As such, this project offers a unique training environment to gain experience in a broad range of chemical and biological laboratory techniques: including synthetic biology, chemical synthesis, microbiology (especially focussed on optimising the growth of various algae) and the analysis of microbial metabolites produced from these experiments using analytical techniques such as HPLC, GC-MS and NMR