fRMI Studies of Emotion and Cognition

描述(申请人提供)：这是一份修改后的K02独立科学家奖续期申请。在最初的获奖期间，PI获得了功能磁共振成像(FMRI)方面的专业知识。技能培养的重点是学习功能磁共振成像方法的基本方面，增加人类神经解剖学的知识，开发在功能磁共振成像过程中使用的激活任务，特别是与研究精神分裂症的神经病理学相关的任务，以及学习使用耶鲁大学功能磁共振成像中心开发的图像处理和数据分析软件。在所要求的K02更新期间，技能发展有两个目标：1)获得学习区域间结构和功能连通性所需的技能；2)学习使用由耶鲁大学以外的研究小组开发的图像分析软件，而不是与PI合作的耶鲁大学小组。在最初供资期间所做的工作导致发表了18篇同行评议的研究论文，目前正在审查另外5篇研究论文。他是其中9篇论文的第一作者和11篇论文的资深作者。在此期间，他一直是9名年轻研究人员的主要研究导师。他们获得了1个R01奖助金和3个基金会奖助金，他是高级合作研究员，以及1个B-Start和5个NARSAD青年调查员奖，他是主要导师。在一次令人鼓舞的审查后，另一笔R01赠款正在重新提交。拟议的研究几乎全部来自两个资助的R01项目。其中一个申请者是私家侦探；另一个是协查人员，他的同事莫里斯·贝尔是私家侦探。第一个R01支持使用记忆测试、结构磁共振和功能磁共振对精神分裂症进行亚型的持续工作。第二个项目支持继续开发和评估电脑化练习，以治疗精神分裂症患者的认知缺陷。这两个项目都提供了发展和应用测量区域间大脑连通性和使用新的分析软件的技能的机会。

DESCRIPTION (provided by applicant): This is a revised application for renewal of a K02 Independent Scientist Award. During the initial award period, the PI gained expertise in functional magnetic resonance imaging (fMRI). Skill development focused on learning basic aspects of fMRI methodology, increasing knowledge of human neuroanatomy, developing activation tasks for use during fMRI with particular relevance for studying the neuropathology of schizophrenia, and learning to use the image processing and data analysis software developed at the Yale fMRI Center. Skill development during the requested K02 renewal has two goals: 1) to acquire skills necessary to study inter-regional structural and functional connectivity; and 2) to learn to use image analysis software developed by research groups other than the Yale group with which the PI has been working. Work done during the initial funding period has led to 18 published peer-reviewed research papers and 5 more research papers are currently under review. The PI is first author on 9 of these papers and senior author on 11. During this period he has been the primary research mentor for 9 younger researchers. They have received 1 R01 grant and 3 foundation grants on which he is the senior co-investigator, and 1 B-START and 5 NARSAD Young Investigator Awards on which he is the primary mentor. Another R01 grant is being resubmitted after an encouraging review. The proposed research comes almost entirely from two funded R01 projects. On one the applicant is the PI; on the other he is the co-investigator and his colleague, Morris Bell, is the PI. The first R01 supports continued work using memory tests, structural MRI and fMRI to subtype schizophrenia. The second project supports continued development and evaluation of computerized exercises to treat the cognitive deficits in people with schizophrenia. Both projects provide opportunities to develop and apply skills in measurement of inter-regional brain connectivity and in use of new analytic software.