fMRI During Simulated Social Interactions in Schizophrenia: Emotion and Cognition

精神分裂症模拟社交互动期间的功能磁共振成像：情绪和认知

• 批准号: 7891276
• 负责人: BRUCE E. WEXLER
• 金额: $ 35.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7891276
• 关键词: Affect; Affective; Amygdaloid structure; Basal Ganglia; Behavior; Behavioral; Brain; Brain Mapping; Brain imaging; Cerebral Dominance; Childhood; Cocaine; Cognition; Cognitive; Cognitive deficits; Competence; Complex; Diagnosis; Disease; Emotional; Emotions; Exposure to; Face; Failure; Family member; Functional Magnetic Resonance Imaging; Gambling; Goals; Imaging Techniques; Impaired cognition; Investigation; Knowledge; Measures; Medial; Methodology; Methods; Neurobiology; Neurosciences Research; Outpatients; Patients; Perception; Performance; Persons; Prefrontal Cortex; Process; Quality of life; Research; Schizophrenia; Short-Term Memory; Simulate; Social Behavior; Social Interaction; Symptoms; Videotape; Voice; Work; affective neuroscience; base; cocaine use; cognitive neuroscience; deficit syndrome; experience; fusiform face area; innovation; neuropathology; positive emotional state; psychologic; relating to nervous system; social; social cognition; social neuroscience; social skills; therapy development; tool

DESCRIPTION (provided by applicant): Social interactions are abnormal in many people with schizophrenia even during childhood before their illnesses are manifest and diagnosed. Limitations in social connectedness discomfort in social interactions poorly developed social skills, blunted and/or socially inappropriate emotion, and emotion- related disturbances of cognition are all features of schizophrenia once manifest and diagnosed. Despite the recognized importance of this complex of social, affective and cognitive disturbances, the associated neurobiological abnormalities have been little studied and are poorly understood. We have developed a new paradigm for studying regional brain activations with fMRI during simulated emotion-evoking social interactions. We created video tapes of actors talking directly to the subjects about happy or sad past personal experiences, and displaying the full range of facial, voice and body manifestations of the emotion. This multidimensional, dynamic and socially contextualized stimulation has greater real world validity than the sequential presentation of still photographs of people's faces typically used in brain imaging studies of social-emotional activation. By comparing brain activations in healthy subjects during these tapes to activations when the actors talked about emotionally-neutral experiences, we identified regional brain activations common to both socially generated emotions and activations specific to each emotion. We also created tapes in which actors pretended to use cocaine or prepare to gamble and asked the subjects to join them as they did. With these and the original tapes we identified brain activation abnormalities in cocaine addicts and pathological gamblers related to their primary pathological behaviors and to emotion-evoking social interactions. The studies proposed in this application would be the first to apply this method to the study of schizophrenia. In earlier work, we demonstrated that cognition and brain laterality were abnormally affected by negative emotion in people with schizophrenia. To investigate this further, we incorporated a working memory task within the video tapes of simulated emotion-evoking social interactions. In preliminary studies of healthy subjects we have demonstrated that happy emotion leads to enhanced cognition-related activation of basal ganglia-thalamocortical circuits. We also propose to use this new methodology to study the effects of socially generated emotion on cognition related brain activation in people with schizophrenia. We predict that positive emotion-evoking social interactions will not enhance cognition-related brain activity in people with schizophrenia as it does in healthy people. Many people with schizophrenia have problems with the expression and understanding of emotion essential in social interactions. These problems precede the diagnosis of illness, are present to some degree in family members, limit patient quality of life and even the ability to participate in treatments. In this project we will use new knowledge from social neuroscience research and newly developed brain imaging procedures to study brain aspects of the patient problems in social-emotional function.

描述（由申请人提供）：许多精神分裂症患者的社会交往是异常的，甚至在他们的疾病明显和诊断之前的童年时期。社会联系的局限性社会交往中的不适社会技能发展不佳，迟钝和/或社交不恰当的情绪，以及情绪相关的认知障碍，一旦表现出来并被诊断出来，都是精神分裂症的特征。尽管人们认识到这种社会、情感和认知障碍的复杂性的重要性，但相关的神经生物学异常却很少被研究，也很少被理解。我们开发了一种新的范例，用于研究在模拟情感唤起的社会互动过程中，用功能磁共振成像（fMRI）研究大脑区域激活。我们制作了演员直接与受试者谈论过去快乐或悲伤的个人经历的录像带，并展示了情感的全方位面部，声音和身体表现。这种多维度的、动态的、社会情境化的刺激比社会情绪激活的脑成像研究中通常使用的连续呈现人脸静止照片具有更大的现实世界有效性。通过比较健康受试者在播放这些磁带时的大脑激活与演员谈论情绪中性经历时的大脑激活，我们确定了社交产生的情绪和每种情绪特有的大脑区域激活。我们还制作了录像带，让演员假装使用可卡因或准备赌博，并要求受试者加入他们的行列。通过这些和原始磁带，我们确定了可卡因成瘾者和病态赌徒的大脑激活异常与他们的主要病理行为和情感唤起的社会互动有关。本应用程序中提出的研究将是第一个将这种方法应用于精神分裂症研究的研究。在早期的工作中，我们证明了精神分裂症患者的认知和大脑偏侧性受到负面情绪的异常影响。为了进一步研究这一点，我们在模拟情感唤起的社会互动的录像带中加入了一个工作记忆任务。在对健康受试者的初步研究中，我们已经证明，快乐情绪导致与认知相关的基底神经节-丘脑皮质回路的激活增强。我们还建议使用这种新方法来研究社会产生的情绪对精神分裂症患者认知相关脑激活的影响。我们预测，积极的唤起情绪的社会互动不会像健康人那样增强精神分裂症患者的认知相关大脑活动。许多精神分裂症患者在表达和理解社交互动中必不可少的情感方面存在问题。这些问题先于疾病的诊断，在某种程度上存在于家庭成员中，限制了患者的生活质量，甚至是参与治疗的能力。在这个项目中，我们将利用社会神经科学研究的新知识和新开发的脑成像程序来研究患者社会情感功能问题的大脑方面。