fRMI Studies of Emotion and Cognition

描述（由申请人提供）：这是一份更新K02独立科学家奖的修订申请。在最初的奖励期间，PI获得了功能磁共振成像（fMRI）方面的专业知识。技能发展的重点是学习功能磁共振成像方法学的基本方面，增加人类神经解剖学的知识，开发与研究精神分裂症的神经病理学特别相关的功能磁共振成像期间使用的激活任务，以及学习使用耶鲁大学功能磁共振成像中心开发的图像处理和数据分析软件。K02更新期间的技能发展有两个目标：1)获得研究区域间结构和功能连通性所需的技能；2)学习使用由耶鲁大学以外的研究小组开发的图像分析软件，而PI一直在与耶鲁大学小组合作。在最初资助期间所做的工作已导致18篇经同行评审的研究论文发表，另有5篇研究论文目前正在接受评审。PI是其中9篇论文的第一作者，11篇论文的资深作者。在此期间，他是9名年轻研究人员的主要研究导师。他们获得了1项R01基金和3项基金资助，其中他是高级共同研究员，以及1项B-START和5项NARSAD青年研究者奖，他是主要导师。在令人鼓舞的审查之后，另一项R01拨款正在重新提交。拟议的研究几乎完全来自两个资助的R01项目。一方面申请人是PI；另一方面，他是联合调查员，他的同事莫里斯·贝尔是私家侦探。第一个R01支持继续使用记忆测试、结构核磁共振成像和功能磁共振成像对精神分裂症亚型进行研究。第二个项目支持继续开发和评估电脑练习，以治疗精神分裂症患者的认知缺陷。这两个项目都为开发和应用测量区域间大脑连接和使用新的分析软件的技能提供了机会。

DESCRIPTION (provided by applicant): This is a revised application for renewal of a K02 Independent Scientist Award. During the initial award period, the PI gained expertise in functional magnetic resonance imaging (fMRI). Skill development focused on learning basic aspects of fMRI methodology, increasing knowledge of human neuroanatomy, developing activation tasks for use during fMRI with particular relevance for studying the neuropathology of schizophrenia, and learning to use the image processing and data analysis software developed at the Yale fMRI Center. Skill development during the requested K02 renewal has two goals: 1) to acquire skills necessary to study inter-regional structural and functional connectivity; and 2) to learn to use image analysis software developed by research groups other than the Yale group with which the PI has been working. Work done during the initial funding period has led to 18 published peer-reviewed research papers and 5 more research papers are currently under review. The PI is first author on 9 of these papers and senior author on 11. During this period he has been the primary research mentor for 9 younger researchers. They have received 1 R01 grant and 3 foundation grants on which he is the senior co-investigator, and 1 B-START and 5 NARSAD Young Investigator Awards on which he is the primary mentor. Another R01 grant is being resubmitted after an encouraging review. The proposed research comes almost entirely from two funded R01 projects. On one the applicant is the PI; on the other he is the co-investigator and his colleague, Morris Bell, is the PI. The first R01 supports continued work using memory tests, structural MRI and fMRI to subtype schizophrenia. The second project supports continued development and evaluation of computerized exercises to treat the cognitive deficits in people with schizophrenia. Both projects provide opportunities to develop and apply skills in measurement of inter-regional brain connectivity and in use of new analytic software.