Examining the importance of DNA damage repair for oocyte quality, female fertility and offspring health

随着女性年龄的增长，她们的卵子质量下降，生下健康宝宝的机会直线下降。卵子内DNA损伤的积累，以及修复这种损伤的能力降低，可能是老年女性生殖成功受损的原因之一。该项目将研究卵子在母亲衰老过程中修复DNA损伤的能力，并将探索DNA修复对生育和将高质量遗传物质传递给后代的重要性。

As women age, the quality of their eggs decline and their chance of having a healthy baby plummets. The accumulation of DNA damage within the egg, and the reduced ability to repair this damage, may be one cause of compromised reproductive success in older women. This project will investigate the ability of eggs to repair DNA damage during maternal aging and will explore the importance of DNA repair to fertility and the transmission of high quality genetic material to their offspring.