Gordon Conference on Myelin

描述（由申请人提供）：在本申请中，我们请求支持将于2004年5月23日至28日在意大利巴尔加的II Ciocci举行的第七届关于髓鞘的戈登会议。 自上次会议以来，髓磷脂生物学领域取得了重大进展，包括对调控髓鞘形成细胞发育关键步骤的转录因子的表征，对控制疾病（如多发性硬化症）中髓鞘再生细胞行为的细胞机制的鉴定，以及轴突-神经胶质连接处分子复合物的解开。新的脱髓鞘动物模型的开发有望为髓鞘的正常功能及其在各种病理学中的功能障碍提供进一步的重要见解。第七次会议的计划已经制定，以突出我们对髓鞘和髓鞘细胞生物学及其在疾病中的作用的理解的新进展。已注意尽量减少发言者与前一次会议或同一年的相关会议的重叠，并将会议的重点扩大到不仅仅是“髓磷脂”。髓鞘和髓鞘形成细胞的生物学的研究是;然而，随着研究膜运输，细胞信号传导和细胞迁移的各个方面的科学家的招募，正在经历一个扩展期。该计划旨在吸引直接研究髓鞘及其相关细胞以及脑肿瘤生物学和再生相关领域的科学家。这种增强的多样性将继续增加髓鞘相关科学家的多样性，并提供一个动态和广谱的会议。为了特别鼓励年轻调查员的参与，将在资金允许的情况下提供登记和旅费津贴。所有与会者将被要求作出贡献的口头报告或提出一个海报。除了正式会议外，广泛的海报会议将鼓励具有不同专业知识的科学家之间的富有成效的互动，并与戈登会议组织的目标保持一致;这种协同作用将为髓鞘生物学领域提供关键的推动力和指导。

DESCRIPTION (provided by applicant): In this application we are requesting support for the seventh Gordon conference on Myelin to be held in II Ciocci, Barga, Italy from May 23-28, 2004. The field of myelin biology has seen significant advances since the last meeting including the characterization of transcription factors regulating critical steps in the development of myelinating cells, the identification of cellular mechanisms that control the behavior of remyelinating cells in diseases such as Multiple Sclerosis and the unraveling of the molecular complexes at axonal-glial junctions. The development of new animal models of demyelination promises to provide further critical insights into the normal function of myelin and its dysfunction in a variety of pathologies. The program for this 7th meeting has been developed to highlight these new advances in our understanding of the biology of myelin and myelinating cells and their role in disease. Care has been taken to minimize overlap in speakers with the previous meeting, or with related meetings in the same year and to expand the focus of the meeting beyond simply "myelin". The study of myelin and the biology of myelinating cells is; however, undergoing a period of expansion with the recruitment of scientists studying diverse aspects of membrane trafficking, cell signaling and cell migration. The program has been designed to attract scientists working both directly on myelin and its associated cells as well as in related areas of brain tumor biology and regeneration. This enhanced diversity will continue to increase the variety of myelin-associated scientist and provide for a dynamic and broad-spectrum meeting. To specifically encourage the participation of young investigators, registration and travel stipends will be offered as funds permit. All attendees will be expected to contribute to an oral presentation or present a poster. In addition to formal sessions, extensive poster sessions will encourage productive interactions between scientists with different expertise and in keeping with the goals of the Gordon Conference organization; such synergy will provide critical impetus and guidance to the field of myelin biology.