Plasminogen Activation/Extracellular Proteolysis Conf.

描述（由申请人提供）：本申请用于部分支持将于2004年2月8日至13日在加州文图拉的Harbortown Sheraton Inn举行的第八届关于纤溶酶原激活和细胞外蛋白水解的Gordon研究会议。这是一个国际会议，以前称为溶栓，自1990年以来每两年举行一次。自成立以来，该会议已从最初的形式发展成为一个更广泛的论坛，深入讨论纤溶酶原激活和细胞外蛋白水解领域最令人兴奋的前沿发展。这一进展在上一次会议上得到了正式认可，会议投票将会议名称改为“纤溶酶原激活和细胞外蛋白水解”。本次会议的主题反映了这一更广泛的范围，并根据以往与会者的意见进行了选择，特别注意了以往主席的建议。基础和临床科学的新进展将被涵盖。重点将放在纤溶酶原激活剂系统和其他蛋白水解系统，包括跨膜丝氨酸蛋白酶和金属蛋白酶，在发展，组织修复，血管疾病，肿瘤进展，血栓溶解，神经元功能，阿尔茨海默病和中风之间的新兴关系。重点将放在对蛋白酶，它们的受体和抑制剂在疾病中的相互作用的机械见解。计划举办九次会议，内容包括： 1.后基因组时代的溶栓治疗 2.纤溶酶原激活与疾病 3.血栓形成和纤维蛋白溶解; 4.神经生物学中的蛋白酶和抑制剂 5.非纤溶酶原依赖性细胞外蛋白水解; 6.合理药物设计与纤溶酶原激活剂 7.最新的主题和精选海报的展示; 8.蛋白酶受体与信号转导 9.跨膜丝氨酸蛋白酶。 因此，会议的目标是提供一个全面的国家的最先进的理解基本生物过程和临床进展有关的细胞外蛋白酶系统在血液和组织。

DESCRIPTION (provided by applicant): This application is for partial support of the eighth Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis to be held at the Harbortown Sheraton Inn in Ventura California on February 8-13, 2004. This is an international conference that was formerly called Thrombolysis, and has been held every two years since 1990. Since its inception, the conference has evolved from its original format into a broader forum for an in-depth discussion of the most exciting, cutting-edge developments in the field of plasminogen activation and extracellular proteolysis. This evolution was formally recognized in the last conference, which voted to change the conference title to "Plasminogen Activation and Extracellular Proteolysis". Topics for the current meeting reflect this broader scope and have been selected based on the input of past attendees, with particular attention to the recommendations of past chairs. New advances in both basic and clinical science will be covered. Emphasis will be placed on emerging relationships between the plasminogen activator system and other proteolytic systems, including transmembrane serine proteases and metalloproteases, in development, tissue repair, vascular disease, tumor progression, thrombolysis, neuronal function, Alzheimer's disease and stroke. Emphasis will be placed on mechanistic insights into interplay of proteases, their receptors, and inhibitors in disease. Nine sessions are planned and will cover: 1. Thrombolysis in the Post Genomic World; 2. Plasminogen Activation and Disease; 3. Thrombosis and Fibrinolysis; 4. Proteases and Inhibitors in Neurobiology; 5. Plasminogen Independent Extracellular Proteolysis; 6. Rational Drug Design and Plasminogen Activators; 7. Late breaking topics and presentation of selected posters; 8. Protease Receptors and Signaling; 9. Transmembrane Serine Proteases. Thus, the goals of the conference are to provide a comprehensive state-of-the-art understanding of basic biologic processes and clinical advances related to extracellular protease systems in blood and tissues.