Novel biomimetic polymer scaffolds for soft tissue reconstruction

软组织是人体的基本组成部分。它们是高度可变形的，使身体的功能。然而，大多数现有的生物材料不能复制天然软组织的结构和性质，限制了软组织修复和重建策略的有效性。该项目旨在制造新型生物相容性和可生物降解的聚合物支架，其形态和机械性能与承重软组织相似，用于再生因疾病，老化或损伤而遭受损失或缺陷的软组织。一系列的聚合物支架将被制备，其结构，机械性能和生物降解动力学的特点。选择具有最佳形态和性能的支架，以评估其在软组织再生中的潜力。聚合物支架的结构-功能关系也将被研究。

Soft tissues are essential constituents of the human body. They are highly deformable, enabling the body's functions. However, the majority of existing biomaterials cannot replicate the structure and properties of native soft tissues, limiting the effectiveness of soft tissue repair and reconstruction strategies. This project aims to manufacture novel biocompatible and biodegradable polymer scaffolds with similar morphologies and mechanical properties to those of a load-bearing soft tissue for the regeneration of soft tissue that has suffered losses or defects due to diseases, aging or injuries. A series of polymer scaffolds will be prepared, with their structure, mechanical properties and biodegradation kinetics characterised. The scaffolds with optimal morphologies and properties will be selected to assess their potential in soft tissue regeneration. The structure-function relationships of the polymer scaffolds will also be investigated.