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Development of non-small cell lung cancer microarrays

Development of non-small cell lung cancer microarrays
非小细胞肺癌微阵列的开发
批准号:
6954042
负责人:
Jin Jen
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
我们构建了一个包含300个NSCLC样本的肺组织微阵列,并对参与几种不同生物学途径的基因进行了系统性检查,以确定其与临床结局的关系。到目前为止,我们已经确定了至少四种蛋白质,其表达的改变在NSCLC中具有预后价值。我们还开发了一个肺癌数据库,可以进行复杂的搜索,包括临床病理信息,患者生存状态和基于免疫组织化学分析的50多种基因产物的蛋白质表达。我们正在继续努力完善数据库,并将组织阵列分析扩展到其他途径和新的蛋白质靶点。
英文摘要
We have constructed a lung tissue microarray containing 300 NSCLC samples and performed systematic examination of genes involved in several distinct biological pathways for their association with clinical outcome. We have so far identified at least four proteins, whose altered expression have prognostic value in NSCLC. We have also developed a lung cancer database that allows complex search included clinical pathological information, patient survival status, and protein expression based on immunohistochemistry analysis for over 50 gene products. We are continuing our effort to refine the database and to expand tissue array analysis to additional pathways and novel protein targets.
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会议论文
Transcriptome map in non-small cell lung cancer
Gene expression profiles in lung cancer using cDNA array
Mechanisms of gene expression changes in lung cancer
Development of non-small cell lung cancer tissue microar
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