Modelling failure mechanisms in total ankle replacement

几十年来，全关节置换术一直是全球数百万患者治疗终末期骨关节炎的一种成功的外科干预措施。尽管如此，全踝关节置换术(TAR)的临床效果一直相对较差--高达20%的植入物在10年前失败。因此，TAR-一种保留关节功能的干预措施-没有踝关节融合-一种限制踝关节活动范围的干预措施-使用得更少。本项目旨在开发实验模拟，通过对失败的取材进行形态和几何分析来模拟全踝关节置换失败的机制-扩大外科医生的范围和先前研究中的装置设计，以确保缓解装置/外科医生特定的失败机制。确定全踝关节置换术中可能出现的功能状态的范围将被用来模拟该装置的生物力学功能。这将提供给复制全踝关节置换生物力学的实验模型，以便实验研究能够产生临床相关的失败机制。

Total joint replacement has been a successful surgical intervention for end-stage osteoarthritis for millions of patients globally for several decades. Despite this, clinical outcomes for total ankle replacement (TAR) have been comparatively poor - with up to 20% of implants failing before 10 years. As a result, TAR - an intervention which preserves joint function - has been used less commonly than ankle fusion - an intervention which limits ankle range of motionThis project aims to develop experimental simulation to model the mechanisms for failure of total ankle replacement through morphological and geometrical analysis of failed retrievals - broadening the range of surgeons and device designs from previous studies to ensure device/surgeon-specific failure mechanisms are mitigated. Determination of the envelope of functional conditions likely in a total ankle replacement will be used to model biomechanical function of the device. This will feed into experimental models that replicate the biomechanics of total ankle replacement such that experimental studies are able to generate clinically relevant failure mechanisms.