Gordon Conf. Macromolecular Organization & Cell Function

描述（由申请人提供）：自1987年以来，戈登大分子组织和细胞功能研究会议每半年举行一次。该提案要求为2004年8月15日至20日举行的这一系列会议中的第十次会议（以及将在牛津大学皇后学院举行的连续第五次会议）提供部分资金。与所有戈登会议一样，这是一个相对较小的会议，仅限于125名与会者。第一次会议集中在酶组织在代谢调节中的作用，但多年来主题已大大拓宽。会议现在涉及细胞功能的核心方面，重点是细胞成分的细胞内组织，控制这种组织的机制，以及细胞内组织在细胞功能中的重要作用。会议主题继续发展，涉及新技术和不同学科的整合可以有效解决的问题。例如，会议的许多重点领域现在与蛋白质组学、代谢组学、结构生物学和生物复杂性等新兴技术的应用特别相关。会议内容包括细胞内部和微结构域、大分子组装的物理化学、细胞功能组织的微结构域、蛋白质组装与细胞骨架、代谢组学：理论与实验、代谢控制中的酶定位、蛋白质-蛋白质相互作用的测量和调节。这是一个真正的跨学科会议，在其历史上，成功地促进了具有不同背景，专业知识和兴趣的科学家之间的思想交流。这些范围从生物化学，细胞生物学和分子生物学领域到生物物理学，物理学和仪器，以及理论生物学和数学建模。跨学科的氛围产生了优秀的讨论和科学互动，这是刺激和高度重视的参与者。鼓励妇女和少数族裔以及研究生、博士后研究员和其他年轻研究人员的参与。虽然该计划的大部分内容现在已经到位，但仍有一些空缺，供人们介绍这一快速发展领域的最新进展，这些进展将于明年初填补。

DESCRIPTION (provided by applicant): The Gordon Research Conference on Macromolecular Organization and Cell Function has met biannually since 1987. This proposal requests partial funding for the tenth conference in this series (and the fifth consecutive one to be held at Queens College, Oxford University), for August 15-20, 2004. As is the case for all Gordon Conferences, this is a relatively small meeting, limited to 125 participants. The first conferences concentrated on the role of enzyme organization in metabolic regulation, but the subject matter has been greatly broadened over the years. The conference now deals with central aspects of cell function, focusing on the intracellular organization of cellular components, the mechanisms underlying and controlling this organization, and the essential role of intracellular organization in cell function. Conference topics continue to evolve in relation to the questions that can be effectively addressed by new technologies and the integration of different disciplines. For example, many of the focus areas of the conference are now especially relevant for the application of emerging technologies in proteomics, metabolomics, structural biology, and biocomplexity. Sessions in the upcoming conference include Cell Interior and Microdomains, Physico-chemistry of Macromolecular Assemblies, Micro-Domains for Organization of Cell Functions, Protein Assemblies with the Cytoskeleton, Metabolomics: Theory and Experiments, Enzyme Localization in the Control of Metabolism, Measurement and Modulation of Protein-Protein Interactions. This is a truly interdisciplinary conference that has, throughout its history, successfully promoted the exchange of ideas among scientists with diverse backgrounds, expertise, and interests. These range from the areas of biochemistry, cell biology, and molecular biology to biophysics, physics, and instrumentation, as well as theoretical biology and mathematical modeling. The interdisciplinary atmosphere produces excellent discussions and scientific interactions that are stimulating and highly valued by the participants. The participation of women and minorities as well as graduate students, postdoctoral fellows and other young investigators is encouraged. Although much of the program is now in place, a number of slots are being kept open for presentations on the most recent developments in this rapidly-moving field, which will be filled early next year.